Estradiol Emulsion


Pronunciation: ES-tra-DYE-ol
Generic Name: Estradiol
Brand Name: Estrasorb

Estradiol Emulsion should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens with or without progestins have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use Estradiol Emulsion. Talk with your doctor if you have questions about the benefits and risks of using Estradiol Emulsion.

Estradiol Emulsion should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use Estradiol Emulsion.


Estradiol Emulsion is used for:

Treating certain conditions caused by menopause (eg, hot flashes; vaginal itching, burning, or dryness).

Estradiol Emulsion is an estrogen hormone used to provide the female hormone when the body no longer produces enough.

Do NOT use Estradiol Emulsion if: you are allergic to any ingredient in Estradiol Emulsion you are pregnant or suspect you may be pregnant you have abnormal vaginal bleeding of unknown cause you have known, suspected, or a history of breast cancer you have known or suspected cancers that are estrogen-dependent you have blood clots (eg, in the legs or lungs) or a history of blood clots you have had a recent (within the past year) heart attack or stroke you have liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Estradiol Emulsion:

Some medical conditions may interact with Estradiol Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are planning to become pregnant if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have had yellowing of the eyes or skin during pregnancy or with past estrogen use if you have asthma, cancer, certain blood disorder (porphyria), depression, diabetes, epilepsy (seizures), eye or vision problems, fluid retention or swelling (edema), gallbladder disease, heart disease or other heart problems, high blood pressure, high cholesterol or triglyceride levels, high or low calcium levels in the blood, kidney problems, a certain type of liver growth (hemangioma), migraine headaches, pancreatitis, or thyroid problems if you have a history of an abnormal mammogram or breast lumps, endometriosis, ovarian cancer, or a family history of breast cancer if you or a family member have a history of blood clots (eg, in the legs or lungs) or lupus, or have been very overweight if you smoke or use tobacco products, you will be having surgery, or you will be on bedrest if you have had your uterus removed (hysterectomy)

Some MEDICINES MAY INTERACT with Estradiol Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, or tacrine because their actions and the risk of their side effects may be increased by Estradiol Emulsion Anticoagulants (eg, warfarin) or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Estradiol Emulsion Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin because they may decrease Estradiol Emulsion's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Estradiol Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Estradiol Emulsion:

Use Estradiol Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Estradiol Emulsion. Talk to your pharmacist if you have questions about this information. If you are switching from oral estrogen to Estradiol Emulsion, stop taking the oral estrogen and wait 1 week before using Estradiol Emulsion. However, if symptoms return, you may start using Estradiol Emulsion sooner. Wash your hands with soap and water both before and after using Estradiol Emulsion. Sit in a comfortable sitting position and apply Estradiol Emulsion to clean, dry skin of the leg. Cut or tear the pouch of medicine and empty the entire contents of the pouch onto the top of the thigh. Rub the medicine in well into the thigh and calf of the leg for 3 minutes until it is completely absorbed. Rub any medicine remaining on the hands onto the buttocks. If you are using two pouches of Estradiol Emulsion, apply the second pouch of medicine to the opposite leg in the same way. Allow the medicine to dry completely before covering with clothing to avoid transfer to other people. Grapefruit and grapefruit juice may increase the risk of Estradiol Emulsion's side effects. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking Estradiol Emulsion. If you miss a dose of Estradiol Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Estradiol Emulsion.

Important safety information: Estradiol Emulsion may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Estradiol Emulsion with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Estradiol Emulsion may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing. Do NOT apply sunscreen to the application site for at least 25 minutes after applying Estradiol Emulsion. Estradiol Emulsion may increase the risk of blood clots. The risk may be greater if you smoke (especially in women older than 35 years). Contact your doctor if vaginal bleeding of unknown cause occurs. This could be a sign of a serious condition requiring immediate medical attention. Contact your doctor if vaginal discomfort occurs or if you suspect you have developed an infection while taking Estradiol Emulsion. Follow your doctor's instructions for examining your breasts, and report any lumps immediately. If you wear contact lenses and you develop problems with them, contact your doctor. If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. You may need to stop taking Estradiol Emulsion at least 4 to 6 weeks beforehand as directed by your doctor. Nonprescription therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor or pharmacist for more details. Estradiol Emulsion may increase the risk of breast and endometrial cancer. Diabetes patients - Estradiol Emulsion may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Estradiol Emulsion may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Estradiol Emulsion. Lab tests, including physical exams and blood pressure, may be performed while you use Estradiol Emulsion. You should have breast and pelvic exams, and a Pap test at least once a year. You should also have periodic mammograms as determined by your doctor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Estradiol Emulsion with caution in the ELDERLY; they may be more sensitive to its effects. Estradiol Emulsion should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Do not use Estradiol Emulsion if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estradiol Emulsion may be found in breast milk. If you are or will be breast-feeding while you use Estradiol Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Estradiol Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast pain or tenderness; headache; hair loss; mild irritation or redness at the application site; mild nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; confusion; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; migraine; muscle pain; one-sided weakness; nipple discharge; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; swelling of the hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes (eg, double vision, loss of vision); weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive vaginal bleeding; severe nausea; vomiting.

Proper storage of Estradiol Emulsion:

Store Estradiol Emulsion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Estradiol Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Estradiol Emulsion, please talk with your doctor, pharmacist, or other health care provider. Estradiol Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Estradiol Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc.


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Skin Barrier Emulsion


Pronunciation: SKIN BAR-ee-er
Generic Name: Skin Barrier
Brand Name: EpiCeram
Skin Barrier Emulsion is used for:

Treating dry skin and relieving the burning and itching associated with certain skin conditions. It may also be used for other conditions as determined by your doctor.

Skin Barrier Emulsion is a steroid-free skin barrier. It works by moisturizing and protecting the skin, which helps relieve skin irritation.

Do NOT use Skin Barrier Emulsion if: you are allergic to any ingredient in Skin Barrier Emulsion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Skin Barrier Emulsion:

Some medical conditions may interact with Skin Barrier Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you are receiving radiation therapy

Some MEDICINES MAY INTERACT with Skin Barrier Emulsion. Because little, if any, of Skin Barrier Emulsion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Skin Barrier Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Skin Barrier Emulsion:

Use Skin Barrier Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Apply a thin layer to the affected area and rub gently into the skin. If the skin is broken, you may cover the area as directed by your doctor. Wash your hands immediately after using Skin Barrier Emulsion unless your hands are part of the treated area. Skin Barrier Emulsion does not contain a sunscreen. Use a sunscreen or wear protective clothing if you will be outside for more than a short time. If you miss a dose of Skin Barrier Emulsion, use it as soon as you remember. Continue to use it as directed by your doctor.

Ask your health care provider any questions you may have about how to use Skin Barrier Emulsion.

Important safety information: Do not apply Skin Barrier Emulsion within 4 hours before radiation therapy. Talk with your doctor before you use any other medicines or cleansers on your skin. You may notice a mild tingling feeling at the application site for a brief time (ie, 10 to 15 minutes) after you apply Skin Barrier Emulsion. This is not a cause for concern. Contact your doctor if you experience severe or persistent skin irritation. If your symptoms do not get better within 10 to 14 days, or if you notice any signs of infection, check with your doctor. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Skin Barrier Emulsion while you are pregnant. It is not known if Skin Barrier Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Skin Barrier Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Skin Barrier Emulsion:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Tingling feeling at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Skin Barrier Emulsion:

Store Skin Barrier Emulsion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Keep Skin Barrier Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Skin Barrier Emulsion, please talk with your doctor, pharmacist, or other health care provider. Skin Barrier Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Skin Barrier Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Skin Barrier resources Skin Barrier Use in Pregnancy & Breastfeeding Skin Barrier Support Group 8 Reviews for Skinrier - Add your own review/rating Compare Skin Barrier with other medications Dry Skin


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Keralac Emulsion


Pronunciation: you-REE-ah
Generic Name: Urea
Brand Name: Examples include Carmol 40 and Keralac
Keralac Emulsion is used for:

Promoting the healing of certain skin conditions (eg, hyperkeratotic conditions). It may also be used for certain other skin conditions (eg, corns; calluses; rough, dry skin) as determined by your doctor.

Keralac Emulsion is a debriding agent. It works by helping the breakdown of dead skin and pus, which helps to loosen and shed hard and scaly skin.

Do NOT use Keralac Emulsion if: you are allergic to any ingredient in Keralac Emulsion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Keralac Emulsion:

Some medical conditions may interact with Keralac Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Keralac Emulsion. Because little, if any, of Keralac Emulsion is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Keralac Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Keralac Emulsion:

Use Keralac Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Keralac Emulsion is for external use only. Shake well before using. Wash hands before and after using Keralac Emulsion unless your hands are part of the treated area. Apply a small amount of Keralac Emulsion to the affected area as directed by your doctor. If you get Keralac Emulsion on any skin that is not part of the treated area, wash it off thoroughly. You may cover the affected area unless directed otherwise by your doctor. If you miss a dose of Keralac Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Keralac Emulsion.

Important safety information: Keralac Emulsion is for external use only. Do not get it in the eyes, nose, or mouth. If you get Keralac Emulsion in the eyes, rinse them immediately with a generous amount of cool water. Do not apply to broken or severely irritated skin. Do not exceed the recommended dose, use Keralac Emulsion for longer than prescribed, or use Keralac Emulsion for other skin conditions without checking with your doctor. PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Keralac Emulsion, discuss with your doctor the benefits and risks of using Keralac Emulsion during pregnancy. It is unknown if Keralac Emulsion is excreted in breast milk. If you are or will be breast-feeding while you are using Keralac Emulsion, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Keralac Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin irritation; temporary burning, stinging, or itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); redness; severe or persistent irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Keralac side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Keralac Emulsion:

Store Keralac Emulsion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Protect from freezing. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Keralac Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Keralac Emulsion, please talk with your doctor, pharmacist, or other health care provider. Keralac Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Keralac Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Keralac resources Keralac Side Effects (in more detail) Keralac Use in Pregnancy & Breastfeeding Keralac Support Group 0 Reviews for Keralac - Add your own review/rating Compare Keralac with other medications Dermatological Disorders Dry Skin Pityriasis rubra pilaris


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Kerol Emulsion


Pronunciation: ue-REE-a/zink/LACK-tik AS-id
Generic Name: Urea in Zinc/Lactic Acid
Brand Name: Examples include Kerol and Latrix XM
Kerol Emulsion is used for:

Aiding in the healing of certain skin conditions (eg, calluses; corns; dermatitis; dry, rough skin; eczema; hyperkeratotic sores; psoriasis). It may also be used for other conditions as determined by your doctor.

Kerol Emulsion is a debriding agent. It works by helping the breakdown of dead skin and pus, which helps to loosen and shed hard and scaly skin.

Do NOT use Kerol Emulsion if: you are allergic to any ingredient in Kerol Emulsion

Contact your doctor or health care provider right away if this applies to you.

Before using Kerol Emulsion:

Some medical conditions may interact with Kerol Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of blood circulation problems or diabetes

Some MEDICINES MAY INTERACT with Kerol Emulsion. Because little, if any, of Kerol Emulsion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Kerol Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Kerol Emulsion:

Use Kerol Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Apply Kerol Emulsion to the affected area as directed by your doctor. Gently rub it in until it is evenly distributed. Wash your hands right away after using Kerol Emulsion, unless your hands are part of the treated area. If you miss a dose of Kerol Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Kerol Emulsion.

Important safety information: Kerol Emulsion is for external use only. Do not get it in your eyes, nose, or mouth. If you get it in any of these areas, rinse right away with cool tap water. Do not use more than the recommended dose or use for longer than prescribed without checking with your doctor. Do not use Kerol Emulsion for other skin conditions without checking with your doctor. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Kerol Emulsion while you are pregnant. It is not known if Kerol Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Kerol Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Kerol Emulsion:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin irritation; temporary burning, stinging, or itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent skin irritation, burning, stinging, or itching.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Kerol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Kerol Emulsion:

Store Kerol Emulsion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Protect from freezing. Store away from heat, moisture, and light. Keep Kerol Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Kerol Emulsion, please talk with your doctor, pharmacist, or other health care provider. Kerol Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Kerol Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Kerol resources Kerol Side Effects (in more detail) Kerol Use in Pregnancy & Breastfeeding Kerol Support Group 0 Reviews for Kerol - Add your own review/rating Compare Kerol with other medications Dermatological Disorders Dry Skin Pityriasis rubra pilaris


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Mineral Oil Emulsion


Pronunciation: MIHN-er-uhl OYL
Generic Name: Mineral Oil
Brand Name: Examples include Kondremul and Liqui-Doss
Mineral Oil Emulsion is used for:

Relieving occasional constipation and bowel irregularity.

Mineral Oil Emulsion is a lubricant laxative that works by slowing the absorption of water from the bowel, which softens the stool.

Do NOT use Mineral Oil Emulsion if: you are allergic to any ingredient in Mineral Oil Emulsion you have a blockage in your intestines you are bedridden

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mineral Oil Emulsion:

Some medical conditions may interact with Mineral Oil Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have heart failure, appendicitis, difficulty swallowing, stomach pain, nausea, vomiting, or rectal bleeding

Some MEDICINES MAY INTERACT with Mineral Oil Emulsion. However, no specific interactions with Mineral Oil Emulsion are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mineral Oil Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mineral Oil Emulsion:

Use Mineral Oil Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Mineral Oil Emulsion on an empty stomach at least 1 hour before or 2 hours after eating. Take Mineral Oil Emulsion at least 2 hours before bedtime. Shake well before using. Pour the measured dose into a drinking glass and add a small amount (less than 2 ounces/30 mL) of water, milk, fruit juice, or soft drink. Stir and drink. Follow with additional liquid if needed. If you miss a dose of Mineral Oil Emulsion, take it as soon as you remember. Continue to take it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Mineral Oil Emulsion.

Important safety information: Do not use this medication for more than 1 week unless directed to do so by your health care provider. Use of Mineral Oil Emulsion for a long time may result in loss of normal bowel function. Do not take additional laxatives or stool softeners with Mineral Oil Emulsion unless directed by your doctor. If you notice a sudden change in bowel habits which lasts for 2 weeks or more, do not continue using Mineral Oil Emulsion. Instead, check with your doctor. Do not take Mineral Oil Emulsion if you have difficulty swallowing without consulting your doctor. Mineral Oil Emulsion is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you are pregnant or plan on becoming pregnant, discuss with your doctor the benefits and risks of using Mineral Oil Emulsion during pregnancy. It is unknown if Mineral Oil Emulsion is excreted in breast milk. If you are or will be breast-feeding, check with your doctor to discuss the risks to your baby. Possible side effects of Mineral Oil Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); failure to have a bowel movement within 12 hours of taking Mineral Oil Emulsion; rectal bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Mineral side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; stomach cramps.

Proper storage of Mineral Oil Emulsion:

Store Mineral Oil Emulsion at room temperature between 59 and 86 degrees F (15 and 30 degrees C) in a tightly closed container. Store away from heat and light. Protect from freezing. Keep Mineral Oil Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Mineral Oil Emulsion, please talk with your doctor, pharmacist, or other health care provider. Mineral Oil Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Mineral Oil Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Mineral Oil resources Mineral Oil Side Effects (in more detail) Mineral Oil Use in Pregnancy & Breastfeeding Mineral Oil Drug Interactions Mineral Oil Support Group 0 Reviews · Be the first to review/rate this drug


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Sumaxin TS Emulsion


Pronunciation: sul-fa-SEE-ta-mide/SULL-fer
Generic Name: Sulfacetamide/Sulfur
Brand Name: Examples include Plexion TS and Sumaxin TS
Sumaxin TS Emulsion is used for:

Treating acne, rosacea, and seborrhea. It may also be used for other conditions as determined by your doctor.

Sumaxin TS Emulsion is a sulfonamide antibiotic and keratolytic. It works by killing bacteria and shedding the top layer of skin to help treat acne.

Do NOT use Sumaxin TS Emulsion if: you are allergic to any ingredient in Sumaxin TS Emulsion you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide you have kidney disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sumaxin TS Emulsion:

Some medical conditions may interact with Sumaxin TS Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have eczema or a history of lupus

Some MEDICINES MAY INTERACT with Sumaxin TS Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Silver-containing products (eg, silver sulfadiazine) because they may decrease Sumaxin TS Emulsion's effectiveness Methenamine because it may increase the risk of Sumaxin TS Emulsion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumaxin TS Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sumaxin TS Emulsion:

Use Sumaxin TS Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sumaxin TS Emulsion is for use on the skin only. Sumaxin TS Emulsion may stain clothing and the skin if too much is used. Wash hands before and after using Sumaxin TS Emulsion. Gently wash and dry the affected area. Apply a small amount of Sumaxin TS Emulsion to the affected area. Rub in gently. To clear up your infection completely, continue using Sumaxin TS Emulsion for the full course of treatment even if you feel better in a few days. Sumaxin TS Emulsion works best if it is used at the same time each day. Continue to use Sumaxin TS Emulsion even if you feel well. Do not miss any doses. If you miss a dose of Sumaxin TS Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumaxin TS Emulsion.

Important safety information: Avoid getting Sumaxin TS Emulsion in your eyes, nose, or mouth. If you get Sumaxin TS Emulsion in your eyes, rinse immediately with cool tap water. Talk with your doctor before you use any other medicines or cleansers on your skin. Do not apply Sumaxin TS Emulsion to open wounds or to damaged or burned skin without first checking with your doctor. If you use topical products too often, your condition may become worse. Sumaxin TS Emulsion only works against bacteria; it does not treat viral infections. Be sure to use Sumaxin TS Emulsion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Long-term or repeated use of Sumaxin TS Emulsion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Sumaxin TS Emulsion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumaxin TS Emulsion while you are pregnant. It is not known if Sumaxin TS Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Sumaxin TS Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Sumaxin TS Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild irritation, stinging, or burning of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cracked or extremely dry skin; fever; joint pain; red, swollen, scaling, or blistered skin; severe diarrhea; sores in the mouth; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Sumaxin TS side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Sumaxin TS Emulsion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Sumaxin TS Emulsion:

Store Sumaxin TS Emulsion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Sumaxin TS Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Sumaxin TS Emulsion, please talk with your doctor, pharmacist, or other health care provider. Sumaxin TS Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sumaxin TS Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Sumaxin TS resources Sumaxin TS Side Effects (in more detail) Sumaxin TS Use in Pregnancy & Breastfeeding Sumaxin TS Drug Interactions 0 Reviews for Sumaxin TS - Add your own review/rating Compare Sumaxin TS with other medications Acne Rosacea Seborrheic Dermatitis


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Zetacet Emulsion


Pronunciation: sul-fa-SEE-ta-mide/SULL-fer
Generic Name: Sulfacetamide/Sulfur
Brand Name: Examples include Plexion TS and Sumaxin TS
Zetacet Emulsion is used for:

Treating acne, rosacea, and seborrhea. It may also be used for other conditions as determined by your doctor.

Zetacet Emulsion is a sulfonamide antibiotic and keratolytic. It works by killing bacteria and shedding the top layer of skin to help treat acne.

Do NOT use Zetacet Emulsion if: you are allergic to any ingredient in Zetacet Emulsion you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide you have kidney disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zetacet Emulsion:

Some medical conditions may interact with Zetacet Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have eczema or a history of lupus

Some MEDICINES MAY INTERACT with Zetacet Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Silver-containing products (eg, silver sulfadiazine) because they may decrease Zetacet Emulsion's effectiveness Methenamine because it may increase the risk of Zetacet Emulsion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zetacet Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zetacet Emulsion:

Use Zetacet Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Zetacet Emulsion is for use on the skin only. Zetacet Emulsion may stain clothing and the skin if too much is used. Wash hands before and after using Zetacet Emulsion. Gently wash and dry the affected area. Apply a small amount of Zetacet Emulsion to the affected area. Rub in gently. To clear up your infection completely, continue using Zetacet Emulsion for the full course of treatment even if you feel better in a few days. Zetacet Emulsion works best if it is used at the same time each day. Continue to use Zetacet Emulsion even if you feel well. Do not miss any doses. If you miss a dose of Zetacet Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zetacet Emulsion.

Important safety information: Avoid getting Zetacet Emulsion in your eyes, nose, or mouth. If you get Zetacet Emulsion in your eyes, rinse immediately with cool tap water. Talk with your doctor before you use any other medicines or cleansers on your skin. Do not apply Zetacet Emulsion to open wounds or to damaged or burned skin without first checking with your doctor. If you use topical products too often, your condition may become worse. Zetacet Emulsion only works against bacteria; it does not treat viral infections. Be sure to use Zetacet Emulsion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Long-term or repeated use of Zetacet Emulsion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Zetacet Emulsion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zetacet Emulsion while you are pregnant. It is not known if Zetacet Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Zetacet Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Zetacet Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild irritation, stinging, or burning of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cracked or extremely dry skin; fever; joint pain; red, swollen, scaling, or blistered skin; severe diarrhea; sores in the mouth; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zetacet side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Zetacet Emulsion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Zetacet Emulsion:

Store Zetacet Emulsion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Zetacet Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Zetacet Emulsion, please talk with your doctor, pharmacist, or other health care provider. Zetacet Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zetacet Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Zetacet resources Zetacet Side Effects (in more detail) Zetacet Use in Pregnancy & Breastfeeding Zetacet Drug Interactions Zetacet Support Group 0 Reviews for Zetacet - Add your own review/rating Compare Zetacet with other medications Acne Rosacea Seborrheic Dermatitis


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Sulfatol Cleanser Emulsion


Pronunciation: sul-fa-SEE-ta-mide/yoor-EE-a
Generic Name: Sulfacetamide/Urea
Brand Name: Examples include Rosula Cleanser and Sulfatol Cleanser
Sulfatol Cleanser Emulsion is used for:

Treating certain skin conditions (eg, seborrheic dermatitis), dandruff, and certain bacterial infections of the skin. It may also be used for other conditions as determined by your doctor.

Sulfatol Cleanser Emulsion is a sulfonamide antibiotic. It works by killing bacteria, helping to shed scaly skin, and softening the skin.

Do NOT use Sulfatol Cleanser Emulsion if: you are allergic to any ingredient in Sulfatol Cleanser Emulsion you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide you are taking methenamine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sulfatol Cleanser Emulsion:

Some medical conditions may interact with Sulfatol Cleanser Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of lupus

Some MEDICINES MAY INTERACT with Sulfatol Cleanser Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Silver-containing products (eg, silver sulfadiazine) because they may decrease Sulfatol Cleanser Emulsion's effectiveness Methenamine because it may increase the risk of Sulfatol Cleanser Emulsion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sulfatol Cleanser Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sulfatol Cleanser Emulsion:

Use Sulfatol Cleanser Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sulfatol Cleanser Emulsion is for use on the skin only. Wash your hands before and immediately after using Sulfatol Cleanser Emulsion. Clean the affected area before applying Sulfatol Cleanser Emulsion. Wet skin and apply plenty of Sulfatol Cleanser Emulsion. Rub gently into the skin for 10 to 20 seconds to form a full lather, rinse completely, and pat dry. To clear up your infection completely, use Sulfatol Cleanser Emulsion for the full course of treatment. Keep using it even if you feel better in a few days. Sulfatol Cleanser Emulsion works best if it is used at the same time each day. Continue to use Sulfatol Cleanser Emulsion even if you feel well. Do not miss any doses. If you miss a dose of Sulfatol Cleanser Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sulfatol Cleanser Emulsion.

Important safety information: It may take several days for Sulfatol Cleanser Emulsion to work fully. Avoid getting Sulfatol Cleanser Emulsion in your eyes, nose, or mouth. Talk with your doctor before you use any other medicines or cleansers on your skin. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Sulfatol Cleanser Emulsion only works against bacteria; it does not treat viral infections. Be sure to use Sulfatol Cleanser Emulsion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Long-term or repeated use of Sulfatol Cleanser Emulsion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Sulfatol Cleanser Emulsion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sulfatol Cleanser Emulsion while you are pregnant. It is not known if Sulfatol Cleanser Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Sulfatol Cleanser Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Sulfatol Cleanser Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritation, stinging, or burning of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; fever; joint pain; red, swollen, or blistered skin; severe diarrhea; sores in the mouth; stomach cramps/pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Sulfatol Cleanser Emulsion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Sulfatol Cleanser Emulsion:

Store Sulfatol Cleanser Emulsion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Sulfatol Cleanser Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Sulfatol Cleanser Emulsion, please talk with your doctor, pharmacist, or other health care provider. Sulfatol Cleanser Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sulfatol Cleanser Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Sulfatol Cleanser resources Sulfatol Cleanser Use in Pregnancy & Breastfeeding Sulfatol Cleanser Support Group 0 Reviews for Sulfatol - Add your own review/rating Compare Sulfatol Cleanser with other medications Dandruff Seborrheic Dermatitis Secondary Cutaneous Bacterial Infections


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Sulfacetamide/Sulfur Emulsion


Pronunciation: sul-fa-SEE-ta-mide/SULL-fer
Generic Name: Sulfacetamide/Sulfur
Brand Name: Examples include Plexion TS and Sumaxin TS
Sulfacetamide/Sulfur Emulsion is used for:

Treating acne, rosacea, and seborrhea. It may also be used for other conditions as determined by your doctor.

Sulfacetamide/Sulfur Emulsion is a sulfonamide antibiotic and keratolytic. It works by killing bacteria and shedding the top layer of skin to help treat acne.

Do NOT use Sulfacetamide/Sulfur Emulsion if: you are allergic to any ingredient in Sulfacetamide/Sulfur Emulsion you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide you have kidney disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sulfacetamide/Sulfur Emulsion:

Some medical conditions may interact with Sulfacetamide/Sulfur Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have eczema or a history of lupus

Some MEDICINES MAY INTERACT with Sulfacetamide/Sulfur Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Silver-containing products (eg, silver sulfadiazine) because they may decrease Sulfacetamide/Sulfur Emulsion's effectiveness Methenamine because it may increase the risk of Sulfacetamide/Sulfur Emulsion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sulfacetamide/Sulfur Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sulfacetamide/Sulfur Emulsion:

Use Sulfacetamide/Sulfur Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sulfacetamide/Sulfur Emulsion is for use on the skin only. Sulfacetamide/Sulfur Emulsion may stain clothing and the skin if too much is used. Wash hands before and after using Sulfacetamide/Sulfur Emulsion. Gently wash and dry the affected area. Apply a small amount of Sulfacetamide/Sulfur Emulsion to the affected area. Rub in gently. To clear up your infection completely, continue using Sulfacetamide/Sulfur Emulsion for the full course of treatment even if you feel better in a few days. Sulfacetamide/Sulfur Emulsion works best if it is used at the same time each day. Continue to use Sulfacetamide/Sulfur Emulsion even if you feel well. Do not miss any doses. If you miss a dose of Sulfacetamide/Sulfur Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sulfacetamide/Sulfur Emulsion.

Important safety information: Avoid getting Sulfacetamide/Sulfur Emulsion in your eyes, nose, or mouth. If you get Sulfacetamide/Sulfur Emulsion in your eyes, rinse immediately with cool tap water. Talk with your doctor before you use any other medicines or cleansers on your skin. Do not apply Sulfacetamide/Sulfur Emulsion to open wounds or to damaged or burned skin without first checking with your doctor. If you use topical products too often, your condition may become worse. Sulfacetamide/Sulfur Emulsion only works against bacteria; it does not treat viral infections. Be sure to use Sulfacetamide/Sulfur Emulsion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Long-term or repeated use of Sulfacetamide/Sulfur Emulsion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Sulfacetamide/Sulfur Emulsion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sulfacetamide/Sulfur Emulsion while you are pregnant. It is not known if Sulfacetamide/Sulfur Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Sulfacetamide/Sulfur Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Sulfacetamide/Sulfur Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild irritation, stinging, or burning of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cracked or extremely dry skin; fever; joint pain; red, swollen, scaling, or blistered skin; severe diarrhea; sores in the mouth; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Sulfacetamide/Sulfur side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Sulfacetamide/Sulfur Emulsion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Sulfacetamide/Sulfur Emulsion:

Store Sulfacetamide/Sulfur Emulsion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Sulfacetamide/Sulfur Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Sulfacetamide/Sulfur Emulsion, please talk with your doctor, pharmacist, or other health care provider. Sulfacetamide/Sulfur Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sulfacetamide/Sulfur Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Sulfacetamide/Sulfur resources Sulfacetamide/Sulfur Side Effects (in more detail) Sulfacetamide/Sulfur Use in Pregnancy & Breastfeeding Sulfacetamide/Sulfur Drug Interactions Sulfacetamide/Sulfur Support Group 18 Reviews for Sulfacetamide/Sulfur - Add your own review/rating Compare Sulfacetamide/Sulfur with other medications Acne Rosacea Seborrheic Dermatitis


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Hypoestrogenism Medications


Drugs associated with Hypoestrogenism

The following drugs and medications are in some way related to, or used in the treatment of Hypoestrogenism. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.


Drug List: Activella Alora Cenestin Climara Clinagen-La-40 Combipatch-Patch-Bi-Weekly Delestrogen Dep-Gynogen Depo-Estradiol Enjuvia Estrace Estrace-Cream Estraderm-Patch Estradiol-Patch Estragyn-La-5 Estratab Estring-Local Gynodiol Gynogen-La-20 Menaval-20 Menest Mimvey Ogen Ogen-0-625 Ogen-1-25 Ogen-2-5 Ortho-Est Premarin Premarin-Injection Vagifem-Local Vivelle-Patch Vivelle-Dot


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Estrasorb Emulsion


Pronunciation: ES-tra-DYE-ol
Generic Name: Estradiol
Brand Name: Estrasorb

Estrasorb Emulsion should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens with or without progestins have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use Estrasorb Emulsion. Talk with your doctor if you have questions about the benefits and risks of using Estrasorb Emulsion.

Estrasorb Emulsion should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use Estrasorb Emulsion.


Estrasorb Emulsion is used for:

Treating certain conditions caused by menopause (eg, hot flashes; vaginal itching, burning, or dryness).

Estrasorb Emulsion is an estrogen hormone used to provide the female hormone when the body no longer produces enough.

Do NOT use Estrasorb Emulsion if: you are allergic to any ingredient in Estrasorb Emulsion you are pregnant or suspect you may be pregnant you have abnormal vaginal bleeding of unknown cause you have known, suspected, or a history of breast cancer you have known or suspected cancers that are estrogen-dependent you have blood clots (eg, in the legs or lungs) or a history of blood clots you have had a recent (within the past year) heart attack or stroke you have liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Estrasorb Emulsion:

Some medical conditions may interact with Estrasorb Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are planning to become pregnant if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have had yellowing of the eyes or skin during pregnancy or with past estrogen use if you have asthma, cancer, certain blood disorder (porphyria), depression, diabetes, epilepsy (seizures), eye or vision problems, fluid retention or swelling (edema), gallbladder disease, heart disease or other heart problems, high blood pressure, high cholesterol or triglyceride levels, high or low calcium levels in the blood, kidney problems, a certain type of liver growth (hemangioma), migraine headaches, pancreatitis, or thyroid problems if you have a history of an abnormal mammogram or breast lumps, endometriosis, ovarian cancer, or a family history of breast cancer if you or a family member have a history of blood clots (eg, in the legs or lungs) or lupus, or have been very overweight if you smoke or use tobacco products, you will be having surgery, or you will be on bedrest if you have had your uterus removed (hysterectomy)

Some MEDICINES MAY INTERACT with Estrasorb Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, or tacrine because their actions and the risk of their side effects may be increased by Estrasorb Emulsion Anticoagulants (eg, warfarin) or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Estrasorb Emulsion Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin because they may decrease Estrasorb Emulsion's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Estrasorb Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Estrasorb Emulsion:

Use Estrasorb Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Estrasorb Emulsion. Talk to your pharmacist if you have questions about this information. If you are switching from oral estrogen to Estrasorb Emulsion, stop taking the oral estrogen and wait 1 week before using Estrasorb Emulsion. However, if symptoms return, you may start using Estrasorb Emulsion sooner. Wash your hands with soap and water both before and after using Estrasorb Emulsion. Sit in a comfortable sitting position and apply Estrasorb Emulsion to clean, dry skin of the leg. Cut or tear the pouch of medicine and empty the entire contents of the pouch onto the top of the thigh. Rub the medicine in well into the thigh and calf of the leg for 3 minutes until it is completely absorbed. Rub any medicine remaining on the hands onto the buttocks. If you are using two pouches of Estrasorb Emulsion, apply the second pouch of medicine to the opposite leg in the same way. Allow the medicine to dry completely before covering with clothing to avoid transfer to other people. Grapefruit and grapefruit juice may increase the risk of Estrasorb Emulsion's side effects. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking Estrasorb Emulsion. If you miss a dose of Estrasorb Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Estrasorb Emulsion.

Important safety information: Estrasorb Emulsion may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Estrasorb Emulsion with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Estrasorb Emulsion may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing. Do NOT apply sunscreen to the application site for at least 25 minutes after applying Estrasorb Emulsion. Estrasorb Emulsion may increase the risk of blood clots. The risk may be greater if you smoke (especially in women older than 35 years). Contact your doctor if vaginal bleeding of unknown cause occurs. This could be a sign of a serious condition requiring immediate medical attention. Contact your doctor if vaginal discomfort occurs or if you suspect you have developed an infection while taking Estrasorb Emulsion. Follow your doctor's instructions for examining your breasts, and report any lumps immediately. If you wear contact lenses and you develop problems with them, contact your doctor. If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. You may need to stop taking Estrasorb Emulsion at least 4 to 6 weeks beforehand as directed by your doctor. Nonprescription therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor or pharmacist for more details. Estrasorb Emulsion may increase the risk of breast and endometrial cancer. Diabetes patients - Estrasorb Emulsion may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Estrasorb Emulsion may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Estrasorb Emulsion. Lab tests, including physical exams and blood pressure, may be performed while you use Estrasorb Emulsion. You should have breast and pelvic exams, and a Pap test at least once a year. You should also have periodic mammograms as determined by your doctor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Estrasorb Emulsion with caution in the ELDERLY; they may be more sensitive to its effects. Estrasorb Emulsion should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Do not use Estrasorb Emulsion if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estrasorb Emulsion may be found in breast milk. If you are or will be breast-feeding while you use Estrasorb Emulsion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Estrasorb Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast pain or tenderness; headache; hair loss; mild irritation or redness at the application site; mild nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; confusion; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; migraine; muscle pain; one-sided weakness; nipple discharge; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; swelling of the hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes (eg, double vision, loss of vision); weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive vaginal bleeding; severe nausea; vomiting.

Proper storage of Estrasorb Emulsion:

Store Estrasorb Emulsion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Estrasorb Emulsion out of the reach of children and away from pets.

General information: If you have any questions about Estrasorb Emulsion, please talk with your doctor, pharmacist, or other health care provider. Estrasorb Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Estrasorb Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc.


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Vivelle


Generic Name: estradiol transdermal (ess tra DYE ol tranz DERM al)
Brand Names: Alora, Climara, Estraderm, Estradiol Patch, Menostar, Vivelle, Vivelle-Dot

What is Vivelle (estradiol transdermal)?

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.

Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol transdermal also reduces urgency or irritation of urination.

Estradiol skin patches are also used to treat ovarian disorders, infertility, and abnormal vaginal bleeding. Some estradiol skin patches are used to prevent postmenopausal osteoporosis. Transdermal skin patches release the drug slowly, and it is absorbed through your skin.

Estradiol transdermal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Vivelle (estradiol transdermal)? Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a bleeding disorder, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding. This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

The estradiol transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. What should I discuss with my healthcare provider before using Vivelle (estradiol transdermal)? Do not use estradiol transdermal if you have:

a bleeding or blood-clotting disorder;

a history of stroke or circulation problems;

abnormal vaginal bleeding that a doctor has not checked; or

any type of breast, uterine, or hormone-dependent cancer.

To make sure you can safely use estradiol transdermal, tell your doctor if you have any of these other conditions:

high blood pressure, angina, or heart disease;

high cholesterol or triglycerides;

liver disease; kidney disease;

asthma;

epilepsy or other seizure disorder;

migraines;

diabetes;

depression;

gallbladder disease; or

if you have had your uterus removed (hysterectomy).

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.

Long-term estradiol treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

FDA pregnancy category X. This medication can cause birth defects. Do not use estradiol transdermal if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby. How should I use Vivelle (estradiol transdermal)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Apply the skin patch to clean, dry skin on your stomach, lower back, or buttocks. Choose a different spot within these skin areas each time you apply a new patch. Avoid skin that is oily, irritated, or damaged.

Press the patch in place firmly for about 10 seconds, especially around the edges.

Do not apply a skin patch to your breasts. Do not apply a patch where it might be rubbed off by tight clothing, such as under an elastic waistband.

If a patch falls off, try putting it back on to a different skin area, pressing the patch into place for 10 seconds. If the patch will not stick you may apply a new one.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

The estradiol transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Apply a skin patch as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra patches to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while using Vivelle (estradiol transdermal)?

Avoid using other estrogen products without your doctor's advice.

Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Vivelle (estradiol transdermal) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden severe headache, confusion, problems with vision, speech, or balance;

pain or swelling in your lower leg;

abnormal vaginal bleeding;

pain, swelling, or tenderness in your stomach;

jaundice (yellowing of the skin or eyes); or

a lump in your breast.

Less serious side effects may include:

nausea, vomiting, loss of appetite;

swollen breasts;

acne or skin color changes;

decreased sex drive, impotence, or difficulty having an orgasm;

migraine headaches or dizziness;

vaginal pain, dryness, or discomfort;

swelling of your ankles or feet;

depression; or

changes in your menstrual periods, break-through bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Vivelle (estradiol transdermal)?

Tell your doctor about all other medicines you use, especially:

carbamazepine (Carbatrol, Equetro, Tegretol);

phenobarbital (Luminal, Solfoton);

St. John's wort;

a blood thinner such as warfarin (Coumadin, Jantoven);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifadin, Rifater, Rifamate, Rimactane), or telithromycin (Ketek);

antifungal medication such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend); or

ritonavir (Norvir, Kaletra) and other HIV/AIDS medications.

This list is not complete and other drugs may interact with estradiol transdermal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Vivelle resources Vivelle Side Effects (in more detail) Vivelle Use in Pregnancy & Breastfeeding Vivelle Drug Interactions Vivelle Support Group 2 Reviews for Vivelle - Add your own review/rating Vivelle Advanced Consumer (Micromedex) - Includes Dosage Information Vivelle Patch MedFacts Consumer Leaflet (Wolters Kluwer) Vivelle Prescribing Information (FDA) Estradiol Monograph (AHFS DI) Estradiol Professional Patient Advice (Wolters Kluwer) Estradiol Prescribing Information (FDA) Estradiol MedFacts Consumer Leaflet (Wolters Kluwer) estradiol Transdermal Advanced Consumer (Micromedex) - Includes Dosage Information Alora Prescribing Information (FDA) Climara Prescribing Information (FDA) Climara Consumer Overview Climara Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer) Delestrogen MedFacts Consumer Leaflet (Wolters Kluwer) Delestrogen Prescribing Information (FDA) Depo-Estradiol MedFacts Consumer Leaflet (Wolters Kluwer) Depo-Estradiol Prescribing Information (FDA) Estrace Prescribing Information (FDA) Estrace MedFacts Consumer Leaflet (Wolters Kluwer) Estrace Consumer Overview Estrace Advanced Consumer (Micromedex) - Includes Dosage Information Estraderm Prescribing Information (FDA) Estradiol Patch Prescribing Information (FDA) Estrasorb Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Estrasorb Consumer Overview Estrasorb Prescribing Information (FDA) Evamist Prescribing Information (FDA) Evamist Consumer Overview Evamist Spray MedFacts Consumer Leaflet (Wolters Kluwer) Femring Prescribing Information (FDA) Femring Ring MedFacts Consumer Leaflet (Wolters Kluwer) Femtrace Prescribing Information (FDA) Femtrace Consumer Overview Femtrace Advanced Consumer (Micromedex) - Includes Dosage Information Femtrace MedFacts Consumer Leaflet (Wolters Kluwer) Menostar Consumer Overview Menostar Prescribing Information (FDA) Menostar Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer) Vivelle-Dot Prescribing Information (FDA) Compare Vivelle with other medications Atrophic Urethritis Atrophic Vaginitis Hypoestrogenism Oophorectomy Osteoporosis Postmenopausal Symptoms Primary Ovarian Failure Where can I get more information? Your pharmacist can provide more information about estradiol transdermal.

See also: Vivelle side effects (in more detail)


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La Prairie Cellular Radiance Emulsion


Generic Name: avobenzone, octinoxate, octisalate
Dosage Form: cream
Cellular Radiance Emulsion

Active Ingredients                        Purpose

Avobenzone 3.0%                        Sunscreen

Octinoxate 7.5%                          Sunscreen

Octisalate  5.0%                        Sunscreen

Warnings

-for external use only

-when using this product keep out of eyes

-rinse with water to remove

-stop use and ask a doctor if rash or irritation develops and lasts

-keep out of reach of children

-do not use on infants under 6 months of age

Uses

-helps prevent sunburn

-for skin that burns easily

-provides moderate protection against sunburn

-higher SPF gives more sunburn protection


Directions

-for external use only

-when using this product keep out of eyes

-rinse with water to remove

-stop use and ask doctor if rash or irritation develops and lasts

-keep out of reach of children

-do not use on infants under 6 months of age

Inactive Ingredients: Water (Aqua), C12-15 Alkyl Ethylhexanoate, Cetyl Alcohol, Glycerin, Helianthus Annuus (Sunflower) Seed Oil, Sea Water (Maris Aqua), Dimethicone, Behenyl Alcohol, Stearyl Alcohol, Butylene Glycol, Propylene Glycol, Caprylic/Capric Triglyceride, Cyclopentasiloxane, Batyl Alcohol, Glycoproteins, Panax Ginseng Root Extract, Equisetum Arvense (Horsetail) Extract, Phytosterols, Silicornia Herbacea Extract, Niacinamide, Hydrolyzed Oat Protein, Alpinia Galang Leaf Extract, Quartz, Disodium Adenosine Triphosphate, Tocopherol, Carica Papaya (Papaya) Fruit Extract, Cholesteryl Nonanoate, Cimicifuga Racemosa Root Extract, Copper Gluconate, PEG-20 Phytosterol, Actinidia Polygama Fruit Extract, Acetyl Heptapeptide-Gold, Cholesteryl Oleate, Dimethylmethoxy Chromanyl Palmitate, Corallina Officinalis Extract, Carbomer, Cholsteryl Stearate, Acrylates Copolymer, Boswellia Serrata Extract, Ammonium Acryloyldimethltaurate/Beheneth-25 Methacrylate Crosspolymer, Phormidium Persicinum Extract, Caprylyl Glycol, Dextran, Magnesium Asparate Glyceryl Stearate, Disodium EDTA, Xanthan Gum, BHT, Fragrance (Parfum), Linalool, Hexyl Cinnamal, Hydroxycitronellal, Alpha-Isomethyl Ionone, Geraniol, Citronellol, Benzyl Benzoate, Butylphenyl Methylpropional, Evernia Furfuracea (Treemoss) Extract, Eugenol, Benzyl Salicylate, Limonene, Phenoxyethanol, Sorbia Acid, Methylparaben, Mica, Titanium Dioxide (CI 77891), Red (CI 14700), Yellow 5 (CI 19140), Gold

Cellular Radiance Emulsion

SPF 30

50 ml / 1.7 Fl. Oz.


LA PRAIRIE SWITZERLAND  CELLULAR RADIANCE EMULSION
avobenzone, octinoxate, octisalate  cream Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 68807-301 Route of Administration TOPICAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AVOBENZONE (AVOBENZONE) AVOBENZONE 3.0 kg  in 100 kg OCTINOXATE (OCTINOXATE) OCTINOXATE 7.5 kg  in 100 kg OCTISALATE (OCTISALATE) OCTISALATE 5.0 kg  in 100 kg Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains          Packaging # NDC Package Description Multilevel Packaging 1 68807-301-11 78.4 kg In 1 DRUM None
Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date OTC monograph not final part352 01/01/2009
Labeler - Temmentec Ag (480586411) Registrant - Temmentec Ag (480586411) Establishment Name Address ID/FEI Operations Temmentec Ag 480586411 manufacture Revised: 05/2010Temmentec Ag
More La Prairie Cellular Radiance Emulsion resources La Prairie Cellular Radiance Emulsion Side Effects (in more detail) La Prairie Cellular Radiance Emulsion Support Group 0 Reviews · Be the first to review/rate this drug


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estradiol and norethindrone


Generic Name: estradiol and norethindrone (ess tra DYE ole and nor ETH in drone)
Brand Names: Activella

What are estradiol and norethindrone?

Estradiol is a form of estrogen. Estrogen is a female sex hormone that is involved in the development and maintenance of the female reproductive system.

Norethindrone is a form of progesterone. Progesterone is a female hormone important for the regulation of ovulation and menstruation.

Together, estradiol and norethindrone are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"); to treat vulvar and vaginal changes (itching, burning, dryness in or around the vagina, difficulty or burning with urination) caused by menopause; and to replace estrogen in conditions such as hypogonadism, removal of the ovaries, or primary ovarian failure that result in a lack of estrogen. Estradiol and norethindrone is also used to prevent thinning of the bones (osteoporosis).

Estradiol and norethindrone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about estradiol and norethindrone?

Estradiol increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Using a progestin, such as norethindrone, with estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking estradiol and norethindrone.

What should I discuss with my healthcare provider before taking estradiol and norethindrone? Do not take estradiol and norethindrone without first talking to your doctor if you have

a circulation, bleeding, or blood-clotting disorder;

undiagnosed, abnormal vaginal bleeding;

any type of breast, uterine, or hormone-dependent cancer; or

liver disease.

Taking estradiol and norethindrone may be dangerous in some cases if you have any of the conditions listed above.

Before taking estradiol and norethindrone, tell your doctor if you have

high blood pressure, angina, or heart disease;

high levels of cholesterol or triglycerides in your blood;

kidney disease;

asthma;

epilepsy;

migraines;

depression;

diabetes;

gallbladder disease;

uterine fibroids; or

had a hysterectomy (uterus removed).

You may not be able to take estradiol and norethindrone, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Estradiol and norethindrone is in the FDA pregnancy category X. This means that estradiol and norethindrone is known to cause birth defects in an unborn baby. Do not take estradiol and norethindrone if you are pregnant or could become pregnant during treatment. Estradiol and norethindrone may decrease milk flow and have other effects on milk composition. Do not take estradiol and norethindrone without first talking to your doctor if you are breast-feeding a baby. How should I take estradiol and norethindrone?

Take estradiol and norethindrone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a glass of water.

Try to take each dose at the same time every day.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking estradiol and norethindrone.

Store ethinyl estradiol and norethindrone tablets at room temperature away from moisture, heat, and direct light.

See also: Estradiol and norethindrone dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose? Contact an emergency room or poison control center for advice if an overdose is suspected.

Symptoms of a estradiol and norethindrone overdose may include nausea, vomiting, and withdrawal bleeding may occur in females.

What should I avoid while using estradiol and norethindrone?

There are no restrictions on food, beverages, or activity while taking estradiol and norethindrone unless otherwise directed by your doctor.

Estradiol and norethindrone side effects If you experience any of the following serious side effects, stop taking estradiol and norethindrone and seek emergency medical attention or notify your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

shortness of breath or pain in the chest;

a painful, red, swollen leg;

abnormal vaginal bleeding;

pain, swelling, or tenderness in the abdomen;

severe headache or vomiting, dizziness, faintness or changes in vision or speech;

yellowing of the skin or eyes; or

a lump in a breast.

Other, less serious side effects may be more likely to occur. Continue to take estradiol and norethindrone and talk to your doctor if you experience

nausea and vomiting;

tenderness or enlargement of the breasts;

weakness;

swelling of the hands or feet;

spotty darkening of the skin, particularly on the face;

difficulty in wearing contact lenses;

vaginal irritation or discomfort; or

changes in menstrual cycle, painful menstruation, or break-through bleeding.

Estradiol increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Using a progestin, such as norethindrone, with estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away.

It is unclear to what extent estrogen and progesterone treatments may affect the risk of breast cancer.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Estradiol and norethindrone Dosing Information

Usual Adult Dose for Atrophic Urethritis:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

Usual Adult Dose for Atrophic Vaginitis:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

Usual Adult Dose for Hypoestrogenism:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

Usual Adult Dose for Postmenopausal Symptoms:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

What other drugs will affect estradiol and norethindrone?

Before taking estradiol and norethindrone, tell your doctor if you are taking an anticoagulant (blood thinner) such as warfarin (Coumadin). You may not be able to take estradiol and norethindrone, or you may require a dosage adjustment or special monitoring during treatment.

Drugs other than those listed here may also interact with estradiol and norethindrone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More estradiol and norethindrone resources Estradiol and norethindrone Dosage Estradiol and norethindrone Use in Pregnancy & Breastfeeding Estradiol and norethindrone Drug Interactions Estradiol and norethindrone Support Group 4 Reviews for Estradiol and norethindrone - Add your own review/rating Compare estradiol and norethindrone with other medications Atrophic Urethritis Atrophic Vaginitis Hypoestrogenism Postmenopausal Symptoms Where can I get more information? Your pharmacist has additional information about estradiol and norethindrone written for health professionals that you may read.


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Aclaro PD Emulsion


hydroquinone
Dosage Form: topical emulsion
Aclaro PD Description Hydroquinone is 1,4-benzenediol.  Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol with a pKa of 9.96. Chemically, hydroquinone is designated as p–dihydroxybenzene; the empirical formula is C6H6O2; molecular weight 110.1. The structural formula is:
ACTIVE INGREDIENT: hydroquinone USP 4%. Other Ingredients: ascorbic acid, benzyl alcohol, butyl methoxydibensoyl methane, C12-15 alkyl benzoate, cetearyl ethylhexanoate, cetyl alcohol, cetyl esters, cetyl palmitate, DEA – cetyl phosphate, dimethicone, dimethylacrylamide/acrylic acid/polystyrene ethyl methacrylate copolymer, disodium EDTA, ethylhexyl methoxycinnamate, glycerine, glycolic acid, hydroxyl ethyl cellulose, phenoxyethanol, propylene glycol (and) BHA (and) citric acid, purified water, sodium hydroxide solution,stearic acid.
Clinical Pharmacology Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa)1 and suppression of other melanocyte metabolic processes.2 Indications and Usage Aclaro PD® is indicated for the gradual treatment of ultraviolet induced dyschromia and discoloration resulting from the use of oral contraceptives, pregnancy, hormone replacement therapy, or skin trauma. Contraindications

Aclaro PD® is contraindicated in any patient that has a prior history of hypersensitivity or allergic reaction to hydroquinone or any of the other ingredients. The safety of topical hydroquinone use during pregnancy or on
children (12 years and under) has not been established.

Warnings A. Caution: Hydroquinone is a depigmenting agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication.
B.Test for skin sensitivity before using Aclaro PD® (hydroquinone USP 4%) bioadhesive emulsion by applying a small amount to an unbroken patch of skin and check within 24 hours. Minor redness is not a contraindication, but where there is itching, vesicle formation, or excessive inflammatory response, further treatment is not advised. Close patient supervision is recommended. Contact with the eyes
should be avoided. If no lightening effect is noted after two months of treatment, use of Aclaro PD® bioadhesive emulsion should be discontinued.
C. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocyte activity. The sunscreens in Aclaro PD® bioadhesive emulsion provide the necessary sun protection during therapy. During and after the use of Aclaro PD® bioadhesive emulsion, sun exposure should be limited or sun-protective clothing should be used to cover the treated areas to prevent repigmentation.
D. Keep this and all medications out of the reach of children. In case of accidental ingestion, contact a physician or poison control center immediately.
E. On rare occasions, a gradual blue-black darkening of the skin may occur. If this occurs, the product should be discontinued and a physician contacted immediately.
Precautions

See Warnings


A. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used in pregnant women only when clearly indicated.

B. Nursing mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when hydroquinone is used by a nursing mother.

C. Pediatric usage: Safety and effectiveness in pediatric patients below the age of 12 years have not been established.


Adverse Reactions No systemic reactions have been reported. Occasional cutaneous hypersensitivity (localized contact dermatitis) may occur, in which case the medication should be discontinued and the physician notified immediately. Overdosage

There have been no systemic reactions reported from the use of topical hydroquinone. However, treatment should be limited to relatively small areas of the body at one time, since some patients experience a transient skin reddening and a mild burning sensation which does not preclude treatment.

Dosage and Administration

Aclaro PD® bioadhesive emulsion should be applied to the affected areas twice daily, or as directed by a physician. There is no recommended dosage for pediatric patients under 12 years of age except under the advice and supervision of a physician.

How Supplied

Aclaro PD® (hydroquinone USP 4%)bioadhesive emulsion is available in a: 1.5 ounce airless pump bottle NDC 68712-015-02

Store at controlled room temperature: 15?-30? C (59?–86? F)


Manufactured for:
Innocutis Holdings LLC
Charleston, SC 29401
Toll free: 1-800-499-4468
www.innocutis.com
www.Aclaro4.com
February 2011
U.S. Pat. No.: 5,942,243


ACLARO PD  HYDROQUINONE
hydroquinone  emulsion Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 68712-015 Route of Administration TOPICAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Hydroquinone (Hydroquinone) Hydroquinone 40 mg  in 1 g Inactive Ingredients Ingredient Name Strength ASCORBIC ACID   BENZYL ALCOHOL   AVOBENZONE   ALKYL (C12-15) BENZOATE   CETEARYL ETHYLHEXANOATE   CETYL ALCOHOL   CETYL ESTERS WAX   CETYL PALMITATE   DIETHANOLAMINE CETYL PHOSPHATE   DIMETHICONE   EDETATE DISODIUM   OCTINOXATE   GLYCERIN   GLYCOLIC ACID   HYDROXYETHYL CELLULOSE (140 CPS AT 5%)   PHENOXYETHANOL   BUTYLATED HYDROXYANISOLE   PROPYLENE GLYCOL   CITRIC ACID MONOHYDRATE   WATER   SODIUM HYDROXIDE   STEARIC ACID   Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains          Packaging # NDC Package Description Multilevel Packaging 1 68712-015-02 42.5 g In 1 BOTTLE, PUMP None
Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 04/01/2011
Labeler - Innocutis Holdings LLC (071501252) Establishment Name Address ID/FEI Operations Sonar Products 104283945 manufacture Revised: 12/2011Innocutis Holdings LLC More Aclaro PD Emulsion resources Aclaro PD Emulsion Side Effects (in more detail) Aclaro PD Emulsion Use in Pregnancy & Breastfeeding Aclaro PD Emulsion Support Group 0 Reviews for Aclaro PD - Add your own review/rating Compare Aclaro PD Emulsion with other medications Dermatological Disorders


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Estrace Vaginal Cream local


Generic Name: estradiol vaginal (local) (ess tra DYE ole VAJ in ul (LO kul))
Brand Names: Estrace Vaginal, Estring, Vagifem

What is estradiol vaginal (local)?

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.

Estradiol vaginal (local) is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol vaginal also reduces urgency or irritation of urination.

Estradiol vaginal (local) may also be used for purposes not listed in this medication guide.

What is the most important information I should know about estradiol vaginal (local)?

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms involving the secretions and surrounding tissues of the vagina. Other vaginal estradiol products are used for treating menopause symptoms affecting the vagina as well as other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is placed or applied.

The information in this leaflet is specific to estradiol vaginal products that are used for local treatment of symptoms.

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding. This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol vaginal.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol.

What should I discuss with my healthcare provider before using estradiol vaginal (local)? You should not use estradiol vaginal if you have:

a bleeding or blood-clotting disorder;

a history of stroke or circulation problems;

abnormal vaginal bleeding that a doctor has not checked; or

any type of breast, uterine, or hormone-dependent cancer.

To make sure you can safely use estradiol vaginal, tell your doctor if you have any of these other conditions:

high blood pressure, angina, or heart disease;

high cholesterol or triglycerides;

liver disease; kidney disease;

asthma;

epilepsy or other seizure disorder;

migraines;

diabetes;

depression;

gallbladder disease; or

if you have had your uterus removed (hysterectomy).

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol vaginal.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use estradiol vaginal if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Long-term estradiol treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Estradiol may decrease breast milk flow and have other effects on milk composition. Do not use estradiol without first talking to your doctor if you are breast-feeding a baby. How should I use estradiol vaginal (local)?

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms involving the secretions and surrounding tissues of the vagina. Other vaginal estradiol products are used for treating menopause symptoms affecting the vagina as well as other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is placed or applied.

The information in this leaflet is specific to estradiol vaginal products that are used for local treatment of symptoms.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

To use the estradiol vaginal ring:

Squeeze the sides of the ring together and insert it into the vagina as far as possible. You should not be able to feel the ring once it is in place. If you can feel it, use a finger to push it in farther. It is not possible for the ring to go too far in or become lost.

Leave the ring in place for 90 days. If the ring ever falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to push it in farther. After 90 days, remove the ring. Your doctor may want you to replace it with a new ring.

The ring does not need to be removed during sexual intercourse. Neither partner should be able to feel the ring when it is in place. If the ring is bothersome, you may remove it, rinse it with warm water, and reinsert it after intercourse.

To remove the ring, loop a finger through the ring and gently pull it from the vagina.

To use the estradiol vaginal cream:

Using the marked applicator provided, measure the prescribed dose of cream.

Lie on your back with your knees drawn up, sit, or stand in a position that allows you comfortable access to the vaginal area. Gently insert the applicator deep into your vagina and press in the plunger to empty the cream from the applicator into the vagina.

Take apart the applicator and wash it with mild soap and warm water. Allow the applicator to dry completely before using it again.

To use the estradiol vaginal tablets:

Each vaginal tablet is supplied in a disposable applicator.

Lie on your back with your knees drawn up, sit, or stand in a position that allows you comfortable access to the vaginal area. Gently insert the applicator deep into your vagina and press in the plunger to empty the tablet into the vagina.

Throw the applicator away.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol vaginal.

Store this medication at room temperature away from moisture and heat. What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

If a vaginal ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to push it in farther.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while using estradiol vaginal (local)?

Avoid using other vaginal products without your doctor's advice.

Estradiol vaginal (local) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

pain, swelling, warmth, or redness in one or both legs;

abnormal vaginal bleeding;

pain, swelling, or tenderness in your stomach;

jaundice (yellowing of the skin or eyes); or

a lump in your breast.

Less serious side effects may include:

nausea, vomiting, loss of appetite;

swollen breasts;

acne or skin color changes;

decreased sex drive, impotence, or difficulty having an orgasm;

migraine headaches or dizziness;

vaginal pain, dryness, or discomfort;

swelling of your ankles or feet;

depression; or

changes in your menstrual periods, break-through bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estradiol vaginal (local)?

Tell your doctor about all other medicines you use, especially:

St. John's wort;

phenobarbital (Solfoton);

a blood thinner such as warfarin (Coumadin, Jantoven);

ritonavir (Norvir, Kaletra);

carbamazepine (Carbatrol, Tegretol);

rifampin (Rifadin, Rifater, Rifamate, Rimactane);

antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole); or

antifungal medicine such as antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend).

This list is not complete and other drugs may interact with estradiol vaginal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Estrace Vaginal Cream resources Estrace Vaginal Cream Side Effects (in more detail) Estrace Vaginal Cream Use in Pregnancy & Breastfeeding Estrace Vaginal Cream Drug Interactions Estrace Vaginal Cream Support Group 12 Reviews for Estrace Vaginal - Add your own review/rating Compare Estrace Vaginal Cream with other medications Atrophic Urethritis Atrophic Vaginitis Hypoestrogenism Where can I get more information? Your pharmacist can provide more information about estradiol vaginal (local).

See also: Estrace Vaginal side effects (in more detail)


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Estradiol Cream


Pronunciation: ES-tra-DYE-ol
Generic Name: Estradiol
Brand Name: Estrace

Estradiol Cream should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use Estradiol Cream. Talk with your doctor if you have questions about the benefits and risks of using Estradiol Cream.

Estradiol Cream should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use Estradiol Cream.


Estradiol Cream is used for:

Treating the wasting of vaginal mucous membranes.

Estradiol Cream is vaginal synthetic female hormone. It works topically to replace hormone levels in women who cannot produce enough hormones to offset menopause symptoms.

Do NOT use Estradiol Cream if: you are allergic to any ingredient in Estradiol Cream you are pregnant or suspect you may be pregnant, have recently given birth or are breast-feeding, have vaginal bleeding of abnormal or unknown cause, or have cancer of the uterus you have known or suspected breast cancer (unless directed by your doctor), or you have cancers that are estrogen-dependent you have blood clots or circulation disorders

Contact your doctor or health care provider right away if any of these apply to you.

Before using Estradiol Cream:

Some medical conditions may interact with Estradiol Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are planning to become pregnant if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a family history of breast cancer, or you have breast lumps or disease, or an abnormal mammogram if you have yellowing of the whites of the eyes or skin during pregnancy or with past estrogen use, or high blood pressure during pregnancy (toxemia) if you have a vaginal infection or womb problems (eg, uterine fibroids/endometriosis, abnormal vaginal bleeding, other uterine problems) if you have abnormal calcium levels in the blood, asthma, cancer (eg, breast), certain blood disorder (porphyria), cholesterol or lipid problems, depression, diabetes, epilepsy, excessive weight gain, gallbladder disease, heart disease or other heart problems, high blood pressure, kidney or liver disease, low thyroid hormone levels, lupus, migraine headaches, pancreas disease, seizures, or yellowing of the skin or eyes if you smoke or will be having surgery

Some MEDICINES MAY INTERACT with Estradiol Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

Blood thinners (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, tacrine or because their actions and the risk of their side effects may be increased by Estradiol Cream Blood thinners (eg, warfarin) because their effectiveness may be decreased by Estradiol Cream Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin because they may decrease Estradiol Cream's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Estradiol Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Estradiol Cream:

Use Estradiol Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Estradiol Cream. Talk to your pharmacist if you have questions about this information. Wash your hands before using Estradiol Cream. Use the supplied applicator to insert the medicine into the vagina. Fill the applicator with medicine according to the directions. Insert the applicator high into the vagina and press the plunger to release the medicine. Wash the applicator with warm soapy water and rinse well after each use. Do not boil or use hot water to clean the applicator. Estradiol Cream may take up to 3 to 4 weeks to reach its maximum effect. If you miss a dose of Estradiol Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Estradiol Cream.

Important safety information: Estradiol Cream may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Estradiol Cream with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Limit alcoholic beverages while you are using Estradiol Cream. Estradiol Cream may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing. Estradiol Cream may increase the risk of blood clots. The risk may be greater if you smoke (especially in women older than 35 years of age). Contact your doctor if vaginal bleeding of unknown cause occurs. This could be a sign of a serious condition requiring immediate medical attention. Contact your doctor if vaginal discomfort occurs or if you suspect you have developed an infection while taking Estradiol Cream. Follow your doctor's instructions for examining your breasts, and report any lumps immediately. If you wear contact lenses and you develop problems with them, contact your doctor. If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Estradiol Cream. Nonprescription therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor or pharmacist for more details. Estradiol Cream may increase the risk of breast and endometrial cancer. Your doctor may prescribe another hormone (progestin) to decrease this risk. Estradiol Cream should be gradually tapered at 3 to 6 month intervals. Diabetes patients - Estradiol Cream may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Estradiol Cream may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Estradiol Cream. Lab tests, including physical exams and blood pressure, may be performed while you use Estradiol Cream. You should have breast and pelvic exams, and a Pap test at least once a year. You should also have periodic mammograms as determined by your doctor. Be sure to keep all doctor and lab appointments. Estradiol Cream should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Do not use Estradiol Cream if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estradiol Cream is found in breast milk. If you are or will be breast-feeding while you use Estradiol Cream, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Estradiol Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast pain or tenderness; headache; hair loss; mild nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain;breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; muscle pain; one-sided weakness; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; sunburn-like rash; swelling of hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive vaginal bleeding; severe nausea; vomiting.

Proper storage of Estradiol Cream:

Store Estradiol Cream at room temperature, 59 to 86 degrees F (15 to 30 degrees C). Store in original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Estradiol Cream out of the reach of children and away from pets.

General information: If you have any questions about Estradiol Cream, please talk with your doctor, pharmacist, or other health care provider. Estradiol Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Estradiol Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Estradiol resources Estradiol Use in Pregnancy & Breastfeeding Estradiol Drug Interactions Estradiol Support Group 21 Reviews for Estradiol - Add your own review/rating Compare Estradiol with other medications Atrophic Urethritis Atrophic Vaginitis Hypoestrogenism


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Norgestrel/Ethinyl Estradiol


Pronunciation: nor-JES-trel/ETH-in-il es-tra-DYE-ole
Generic Name: Norgestrel/Ethinyl Estradiol
Brand Name: Examples include Lo/Ovral and Ogestrel

Smoking cigarettes while using Norgestrel/Ethinyl Estradiol increases your chance of having heart problems. Do not smoke while using Norgestrel/Ethinyl Estradiol. The risk of heart problems increases with age and with frequent smoking. Women older than 35 years of age and women who smoke 15 or more cigarettes per day are at a greater risk for heart problems.


Norgestrel/Ethinyl Estradiol is used for:

Preventing pregnancy. It may also be used for other conditions as determined by your doctor.

Norgestrel/Ethinyl Estradiol is a combination birth control pill. It works by preventing ovulation, altering the cervical mucus, and changing the lining of the uterus.

Do NOT use Norgestrel/Ethinyl Estradiol if: you are allergic to any ingredient in Norgestrel/Ethinyl Estradiol you have a history of blood clotting problems; heart disease; irregular heartbeat due to clotting problems; blood vessel problems (eg, blood flow problems in the brain or heart, stroke); chest pain (eg, heart attack, angina); certain types of headaches or migraines; uncontrolled high blood pressure; diabetes that affects circulation; breast cancer; endometrial, cervical, or vaginal cancer; estrogen-dependent growths; undiagnosed vaginal bleeding; yellowing of the eyes or skin due to pregnancy or prior birth control use; or liver disease or tumors you know or suspect that you are pregnant you have had surgery and are confined to a bed or a chair for an extended period of time

Contact your doctor or health care provider right away if any of these apply to you.

Before using Norgestrel/Ethinyl Estradiol:

Some medical conditions may interact with Norgestrel/Ethinyl Estradiol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have endometriosis, growths in the uterus, abnormal mammogram, irregular menstrual periods, a lump in the breast, heart problems, diabetes, headaches or migraines, gallbladder problems, high blood pressure, high blood cholesterol or lipid levels, kidney problems, blood problems (eg, porphyria), blood in the urine, depression or other mental/mood problems, lupus, chorea, high blood calcium levels, yellowing of the eyes or skin, pancreas problems (eg, pancreatitis), seizures (eg, epilepsy), or a history of cancer if you are overweight, you have not yet had your first menstrual period, or you use tobacco

Some MEDICINES MAY INTERACT with Norgestrel/Ethinyl Estradiol. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, azole antifungals (eg, ketoconazole, itraconazole), barbiturates (eg, phenobarbital), bosentan, carbamazepine, dexamethasone, felbamate, griseofulvin, HIV protease inhibitors (eg, ritonavir), hydantoins (eg, phenytoin), modafinil, nevirapine, oxcarbazepine, penicillins (eg, amoxicillin), rifabutin, rifampin, phenylbutazone, primidone, tetracyclines (eg, doxycycline), topiramate, troglitazone, or St. John's wort because the effectiveness of Norgestrel/Ethinyl Estradiol may be decreased, resulting in breakthrough bleeding or pregnancy Atorvastatin, indinavir, or troleandomycin because they may increase the risk of Norgestrel/Ethinyl Estradiol's side effects. Beta-blockers (eg, propranolol), corticosteroids (eg, prednisolone), cyclosporine, or theophylline because the risk of their side effects may be increased by Norgestrel/Ethinyl Estradiol Clofibric acid, morphine, lamotrigine, salicylic acid, or temazepam because their effectiveness may be decreased by Norgestrel/Ethinyl Estradiol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Norgestrel/Ethinyl Estradiol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Norgestrel/Ethinyl Estradiol:

Use Norgestrel/Ethinyl Estradiol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Norgestrel/Ethinyl Estradiol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Begin taking Norgestrel/Ethinyl Estradiol on the first Sunday following the start of your period, unless otherwise directed by your doctor. If your period begins on a Sunday, begin taking Norgestrel/Ethinyl Estradiol on that day. Try to take Norgestrel/Ethinyl Estradiol at the same time every day, not more than 24 hours apart. After taking the last pill in the pack, start taking the first pill from a new pack the very next day. Norgestrel/Ethinyl Estradiol works best if it is taken at the same time each day. Do not skip doses. If you miss 1 dose of Norgestrel/Ethinyl Estradiol, take it as soon as you remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. If you miss more than 1 dose of Norgestrel/Ethinyl Estradiol, read the extra patient information leaflet that comes with Norgestrel/Ethinyl Estradiol or contact your doctor for instructions. If you miss 1 or more doses of Norgestrel/Ethinyl Estradiol, you must use a backup form of birth control for 7 days after you start to take it again. If you are not sure about how to handle miss doses, use an extra form of birth control (eg, condoms) and talk with your doctor.

Ask your health care provider any questions you may have about how to use Norgestrel/Ethinyl Estradiol.

Important safety information: Norgestrel/Ethinyl Estradiol may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Norgestrel/Ethinyl Estradiol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Follow your doctor's instructions for examining your own breasts and report any lumps immediately. If you will be having surgery or will be confined to a bed or chair for a long period of time (such as a long plane flight), notify your doctor 3 to 4 weeks ahead of time. Special precautions may need to be taken in these circumstances while taking Norgestrel/Ethinyl Estradiol. Norgestrel/Ethinyl Estradiol may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protected clothing when exposed to the sun, sunlamps, or tanning booths. Use of Norgestrel/Ethinyl Estradiol will not prevent the spread of sexually transmitted diseases (STDs). Bleeding or spotting may occur while taking Norgestrel/Ethinyl Estradiol. Do not stop taking Norgestrel/Ethinyl Estradiol if this occurs. If bleeding or spotting continues for more than 7 days or is heavy, contact your doctor. Norgestrel/Ethinyl Estradiol may increase the risk of stroke, heart attack, blood clots, high blood pressure, or similar problems. The risk may be greater if you smoke. Norgestrel/Ethinyl Estradiol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Norgestrel/Ethinyl Estradiol. Taking certain antibiotics, anticonvulsants, or other medicines, as listed in the interactions section, while you are using Norgestrel/Ethinyl Estradiol may decrease the effectiveness of Norgestrel/Ethinyl Estradiol. To prevent pregnancy, use an extra form of birth control until your next period. If you wear contact lens and you develop problems with them, contact your doctor. If you miss your period during the week of inactive pills, call your doctor immediately. A missed period may indicate that you are pregnant. Norgestrel/Ethinyl Estradiol may take time to wear off after your last dose. You may not be able to become pregnant for several months after stopping Norgestrel/Ethinyl Estradiol. Discuss any concerns with your doctor or pharmacist. Lab tests, including PAP tests, may be performed while you use Norgestrel/Ethinyl Estradiol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Norgestrel/Ethinyl Estradiol is not recommended for use in CHILDREN who have not had their first menstrual period. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: Do not use Norgestrel/Ethinyl Estradiol if you are pregnant. If you think you may be pregnant, contact your doctor right away. Norgestrel/Ethinyl Estradiol is found in breast milk. Do not breast-feed while taking Norgestrel/Ethinyl Estradiol. Possible side effects of Norgestrel/Ethinyl Estradiol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; breast tenderness or enlargement; changes in appetite; changes in weight; dizziness; headache; mild hair loss; nausea; nervousness; stomach cramps or bloating; vaginal spotting or breakthrough bleeding.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue, unusual hoarseness); absent menstrual period; breast discharge; breast lumps; calf or leg pain, swelling, or tenderness; change in the amount of urine produced; chest pain or heaviness; confusion; coughing of blood; dark urine; fainting; mental or mood changes (eg, depression); migraines; numbness of an arm or leg; one-sided weakness; pale stools; persistent, severe, or recurring headache or dizziness; persistent vaginal spotting; severe pain or tenderness in the stomach; shortness of breath; slurred speech; sudden severe headache or vomiting; swelling of the fingers, hands, legs, or ankles; unusual or severe vaginal bleeding; unusual tiredness or weakness; vaginal irritation, discharge, or change in secretions; vision changes (eg, sudden vision loss, double vision); yellowing of the skin or eyes (with or without fever).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include nausea; vaginal bleeding; vomiting.

Proper storage of Norgestrel/Ethinyl Estradiol:

Store Norgestrel/Ethinyl Estradiol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Norgestrel/Ethinyl Estradiol out of the reach of children and away from pets.

General information: If you have any questions about Norgestrel/Ethinyl Estradiol, please talk with your doctor, pharmacist, or other health care provider. Norgestrel/Ethinyl Estradiol is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Norgestrel/Ethinyl Estradiol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Norgestrel/Ethinyl Estradiol resources Norgestrel/Ethinyl Estradiol Dosage Norgestrel/Ethinyl Estradiol Use in Pregnancy & Breastfeeding Norgestrel/Ethinyl Estradiol Drug Interactions Norgestrel/Ethinyl Estradiol Support Group 45 Reviews for Norgestrel/Ethinyl Estradiol - Add your own review/rating Compare Norgestrel/Ethinyl Estradiol with other medications Abnormal Uterine Bleeding Birth Control Emergency Contraception Endometriosis Gonadotropin Inhibition


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estradiol and norethindrone topical patches


Generic Name: estradiol and norethindrone (topical patches) (ess tra DYE all and nor ETH in drone)
Brand Names: Combipatch

What are estradiol and norethindrone?

Estradiol is a form of estrogen. Estrogen is a female sex hormone that is involved in the development and maintenance of the female reproductive system.

Norethindrone is a form of progesterone. Progesterone is a female hormone important for the regulation of ovulation and menstruation.

Together, estradiol and norethindrone are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"); to treat vulvar and vaginal changes (itching, burning, dryness in or around the vagina, difficulty or burning with urination) caused by menopause; and to replace estrogen in conditions such as hypogonadism, removal of the ovaries, or primary ovarian failure that result in a lack of estrogen.

Estradiol and norethindrone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about estradiol and norethindrone?

Estradiol increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Using a progestin, such as norethindrone, with estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away.

Treatment with estrogens long-term may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before using estradiol and norethindrone long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol and norethindrone.

Do not use this medication if you are pregnant. Do not place the transdermal patch on your breasts or at your waistline where tight-fitting clothing may interfere with its functioning. What should I discuss with my healthcare provider before using estradiol and norethindrone? Do not use estradiol and norethindrone without first talking to your doctor if you have

a circulation, bleeding, or blood-clotting disorder;

undiagnosed, abnormal vaginal bleeding; or

any type of breast, uterine, or hormone-dependent cancer. or

Using estradiol and norethindrone may be dangerous in some cases if you have any of the conditions listed above.

Before using estradiol and norethindrone, tell your doctor if you have

high blood pressure, angina, or heart disease;

high levels of cholesterol or triglycerides in your blood;

kidney disease; liver disease;

asthma;

epilepsy;

migraines;

depression;

diabetes;

gallbladder disease;

uterine fibroids; or

had a hysterectomy (uterus removed).

You may not be able to use estradiol and norethindrone, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Estradiol and norethindrone is in the FDA pregnancy category X. This means that estradiol and norethindrone will cause birth defects in an unborn baby. Do not use estradiol and norethindrone if you are pregnant or could become pregnant during treatment. Estradiol and norethindrone may decrease milk flow and have other effects on milk composition. Do not use estradiol and norethindrone without first talking to your doctor if you are breast-feeding a baby. How should I use estradiol and norethindrone?

Use estradiol and norethindrone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To use estradiol and norethindrone patches:

Apply each patch to a smooth (fold free), clean, dry area on your lower abdomen. The area should not be oily, damaged, or irritated.

Do not use the patch on your breasts or at your waistline, where clothing may interfere with its use.

After opening a pouch, remove one side of the protective liner, taking care not to touch the adhesive part with your fingers. Immediately apply the patch. Remove the second side of the protective liner and press the patch firmly in place with your hand for at least 10 seconds, making sure there is good contact, especially around the edges.

Replace the patch on the same two days each week (every 3 to 4 days) as directed by your doctor. Only one patch should be worn at any time.

Allow at least 1 week to pass between applications of the patch to a given area.

Do not cut the patches. After a patch is in place, it should not be exposed the sun for prolonged periods of time.

Take care so the patch does not come off during bathing or other activities. If a patch falls off for any reason, reapply it to another site on your lower abdomen. If it will not stick, apply a new patch to a new site. Continue changing the patch on your regular schedule.

Removal of the patch should be done carefully and slowly to avoid irritation of the skin. If any adhesive remains on the skin, allow it to dry for 15 minutes. Then gently rub the area with an oil-based cream or lotion.

Your doctor may prescribe two different patches for you. In this treatment regimen, use the estrogen-only patch for the first 14 days of a 28-day cycle, according to the product directions. Then, use the estradiol and norethindrone patches for the remaining 14 days, according to the product directions. Follow your doctor's instructions or ask your pharmacist for help if you do not remember. Monthly withdrawal bleeding often occurs with this regimen.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol and norethindrone.

Store the patches in their sealed foil pouches at room temperature away from moisture, heat, and direct light for up to 6 months from the date you receive them from the pharmacy or the expiration date, whichever comes first. What happens if I miss a dose?

Apply the next patch as soon as you remember. Continue to follow your regular schedule for changing the patch. Do not use two patches simultaneously unless your doctor directs otherwise.

If a patch falls off for any reason, reapply it to another site on your lower abdomen. If it will not stick, apply a new patch to a new site. Continue changing the patch on your regular schedule.

What happens if I overdose? An overdose of estradiol and norethindrone is unlikely to occur and is not likely to threaten life. If you do suspect an overdose, or if a patch has been ingested, call an emergency room or poison control center for advice.

Symptoms of a estradiol and norethindrone overdose may include nausea, vomiting, and withdrawal bleeding may occur in females.

What should I avoid while using estradiol and norethindrone? After a patch is in place, it should not be exposed the sun for prolonged periods of time.

There are no restrictions on food, beverages, or activity while using estradiol and norethindrone unless your doctor directs otherwise.

Estradiol and norethindrone side effects

Treatment with estrogens long-term may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before using estradiol and norethindrone long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.

If you experience any of the following serious side effects, stop using estradiol and norethindrone and seek emergency medical attention or notify your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

sharp chest pain, coughing of blood or shortness of breath (possible blood clot in the lung );

pain in the calf (possible blood clot in the leg);

crushing chest pain or heaviness in the chest (possible heart attack);

sudden severe headache or vomiting, dizziness or fainting, disturbances of vision or speech, weakness, or numbness in an arm or leg (possible stroke);

partial or complete loss of vision (possible clot in the eye);

stomach pain or tenderness, yellowing of the skin or eyes, fever, fatigue, loss of appetite, dark-colored urine, or light-colored stools (possible liver problems); or

new or changing breast lumps.

Other, less serious side effects may be more likely to occur. Continue to use estradiol and norethindrone and talk to your doctor if you experience

nausea and vomiting;

tenderness or enlargement of the breasts;

weakness;

swelling of the hands or feet;

spotty darkening of the skin, particularly on the face;

difficulty in wearing contact lenses;

vaginal irritation or discomfort;

a rash or reaction at the patch application site; or

changes in menstrual cycle, painful menstruation, or breakthrough bleeding.

Estradiol increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Using a progestin, such as norethindrone, with estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Estradiol and norethindrone Dosing Information

Usual Adult Dose for Atrophic Urethritis:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

Usual Adult Dose for Atrophic Vaginitis:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

Usual Adult Dose for Hypoestrogenism:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

Usual Adult Dose for Postmenopausal Symptoms:

One (1 mg estradiol/0.5 mg norethindrone or 0.5 estradiol/ 0.1 mg norethindrone) tablet orally once a day.
-or-
One (0.05 mg-0.14 mg) patch applied twice weekly. If a greater progestin dose is desired, a single (0.05 mg-0.25 mg) patch may be applied twice weekly.
Alternatively, either patch may be applied as a continuation to an initial 14-day application of an estradiol-only transdermal patch within a 28-day cycle.
The patch should not be applied to, or near, the breasts. The application site should be smooth, clean, dry, fold-free, without damage or irritation, and be rotated with an interval of at least one week allowed to pass between applications to the same site.
If a patch dislodges, it may be reapplied to another area of the lower abdomen, or a new patch may be applied, in which case, the original treatment schedule resumes. However, only one patch should be worn at any given time during the three to four day dosing interval.

What other drugs will affect estradiol and norethindrone?

Before using estradiol and norethindrone, tell your doctor if you are taking an anticoagulant (blood thinner) such as warfarin (Coumadin). You may not be able to use estradiol and norethindrone, or you may require a dosage adjustment or special monitoring during treatment if you are taking warfarin (Coumadin).

Drugs other than those listed here may also interact with estradiol and norethindrone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

More estradiol and norethindrone resources Estradiol and norethindrone Dosage Estradiol and norethindrone Use in Pregnancy & Breastfeeding Estradiol and norethindrone Drug Interactions Estradiol and norethindrone Support Group 4 Reviews for Estradiol and norethindrone - Add your own review/rating Compare estradiol and norethindrone with other medications Atrophic Urethritis Atrophic Vaginitis Hypoestrogenism Postmenopausal Symptoms Where can I get more information? Your pharmacist has additional information about estradiol and norethindrone written for health professionals that you may read.


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Estradiol


Pronunciation: ES-tra-DYE-ol
Generic Name: Estradiol
Brand Name: Examples include Estrace and Gynodiol

Estradiol should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use Estradiol. Talk with your doctor if you have questions about the benefits and risks of using Estradiol.

Estradiol should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use Estradiol.


Estradiol is used for:

Treating conditions due to menopause (eg, hot flashes; vaginal itching, burning, or dryness), treating vulval or vaginal atrophy, and preventing osteoporosis (brittle bones). It is also used for estrogen replacement therapy after failure of the ovaries and to relieve the symptoms of breast cancer.

Treating advanced prostate cancer. It is also used to relieve symptoms of breast cancer.

Estradiol is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.It works for advanced prostate cancer by antagonizing male hormones.

Do NOT use Estradiol if: you are allergic to any ingredient in Estradiol you are pregnant or suspect you may be pregnant, have recently given birth or are breast-feeding, or have vaginal bleeding of abnormal or unknown cause you have known or suspected breast cancer (unless directed by your doctor) or you have cancers that are estrogen-dependent you have blood clots, vein inflammation, or liver disease you have had a recent stroke or heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Estradiol:

Some medical conditions may interact with Estradiol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are planning to become pregnant if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a family history of breast cancer, or you have breast lumps or disease, or an abnormal mammogram if you have yellowing of the whites of the eyes or skin during pregnancy or with past estrogen use, or high blood pressure during pregnancy (toxemia) if you have a vaginal infection or womb problems (eg, uterine fibroids/endometriosis, abnormal vaginal bleeding, other uterine problems) if you have abnormal calcium levels in the blood, asthma, cancer, certain blood disorder (porphyria), cholesterol or lipid problems, depression, diabetes, epilepsy, excessive weight gain, gallbladder disease, heart disease or other heart problems, high blood pressure, kidney or liver disease, low thyroid hormone levels, lupus, migraine headaches, pancreas disease, seizures, or yellowing of the skin or eyes if you smoke or will be having surgery

Some MEDICINES MAY INTERACT with Estradiol. Tell your health care provider if you are taking any other medicines, especially any of the following:

Blood thinners (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, or tacrine because their actions and the risk of their side effects may be increased by Estradiol Blood thinners (eg, warfarin) because their effectiveness may be decreased by Estradiol Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin because they may decrease Estradiol's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Estradiol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Estradiol:

Use Estradiol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Estradiol. Talk to your pharmacist if you have questions about this information. Take Estradiol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Grapefruit and grapefruit juice may increase the risk of Estradiol's side effects. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking Estradiol. If you miss a dose of Estradiol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Estradiol.

Important safety information: Estradiol may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Estradiol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Limit alcoholic beverages while you are taking Estradiol. Estradiol may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing. Estradiol may increase the risk of blood clots. The risk may be greater if you smoke (especially in women older than 35 years of age). Contact your doctor if vaginal bleeding of unknown cause occurs. This could be a sign of a serious condition requiring immediate medical attention. Contact your doctor if vaginal discomfort occurs or if you suspect you have developed an infection while taking Estradiol. Follow your doctor's instructions for examining your breasts and report any lumps immediately. Additional monitoring of your dose or condition may be necessary if you are presently taking an azole antifungal (eg, itraconazole), carbamazepine, a macrolide antibiotic (eg, erythromycin), ritonavir, cimetidine, or St. John's wort. If you wear contact lenses and you develop problems with them, contact your doctor. If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Estradiol. Nonprescription therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor or pharmacist for more details. Some of these products may contain the dye tartrazine (FD&C Yellow No. 5), which can cause allergic reactions in certain patients. Consult your doctor or pharmacist. If you previously had allergic reactions to the dye tartrazine, contact your doctor or pharmacist to determine if the product you are taking contains the dye tartrazine. Estradiol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Estradiol. Diabetes patients - Estradiol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lab tests, including physical exams and blood pressure, may be performed while you use Estradiol. You should have breast and pelvic exams, and a Pap test at least once a year. You should also have periodic mammograms as determined by your doctor. Be sure to keep all doctor and lab appointments. Estradiol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Do not use Estradiol if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estradiol may be found in breast milk. If you are or will be breast-feeding while you use Estradiol, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Estradiol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast pain or tenderness; headache; hair loss; mild nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain;breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; muscle pain; one-sided weakness; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; sunburn-like rash; swelling of hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive vaginal bleeding; severe nausea; vomiting.

Proper storage of Estradiol:

Store Estradiol at room temperature, 59 to 86 degrees F (15 to 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Estradiol out of the reach of children and away from pets.

General information: If you have any questions about Estradiol, please talk with your doctor, pharmacist, or other health care provider. Estradiol is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Estradiol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Estradiol resources Estradiol Use in Pregnancy & Breastfeeding Drug Images Estradiol Drug Interactions Estradiol Support Group 57 Reviews for Estradiol - Add your own review/rating Estradiol Monograph (AHFS DI) Estradiol Prescribing Information (FDA) Estradiol Professional Patient Advice (Wolters Kluwer) estradiol Transdermal Advanced Consumer (Micromedex) - Includes Dosage Information Alora Advanced Consumer (Micromedex) - Includes Dosage Information Alora Prescribing Information (FDA) Climara Consumer Overview Climara Prescribing Information (FDA) Delestrogen Prescribing Information (FDA) Depo-Estradiol Prescribing Information (FDA) Estrace Prescribing Information (FDA) Estrace Advanced Consumer (Micromedex) - Includes Dosage Information Estrace Consumer Overview Estraderm Prescribing Information (FDA) Estradiol Patch Prescribing Information (FDA) Estrasorb Consumer Overview Estrasorb Prescribing Information (FDA) Evamist Consumer Overview Evamist Prescribing Information (FDA) Femring Prescribing Information (FDA) Femtrace Advanced Consumer (Micromedex) - Includes Dosage Information Femtrace Consumer Overview Femtrace Prescribing Information (FDA) Menostar Consumer Overview Menostar Prescribing Information (FDA) Vivelle Prescribing Information (FDA) Vivelle-Dot Prescribing Information (FDA) Compare Estradiol with other medications Atrophic Urethritis Atrophic Vaginitis Breast Cancer, Palliative Hypoestrogenism Oophorectomy Osteoporosis Postmenopausal Symptoms Primary Ovarian Failure Prostate Cancer


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