Myasthenia Gravis Medications


Definition of Myasthenia Gravis: Myasthenia gravis is a neuromuscular disorder characterized by variable weakness of voluntary muscles, which often improves with rest and worsens with activity. The condition is caused by an abnormal immune response.

Drugs associated with Myasthenia Gravis

The following drugs and medications are in some way related to, or used in the treatment of Myasthenia Gravis. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Myasthenia Gravis

Micromedex Care Notes:

Myasthenia Gravis

Medical Encyclopedia:

Myasthenia gravis

Harvard Health Guide:

Symptoms and treatment for Myasthenia Gravis
Drug List: Mestinon Mestinon-Timespan Mytelase Mytelase-Chloride Prostigmin Prostigmin-Bromide Regonol Soliris
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Mestinon Controlled-Release Tablets


Pronunciation: peer-id-oh-STIG-meen
Generic Name: Pyridostigmine
Brand Name: Mestinon
Mestinon Controlled-Release Tablets are used for:

Treating myasthenia gravis. It may also be used for other conditions as determined by your doctor.

Mestinon Controlled-Release Tablets are a cholinesterase inhibitor. It works by improving nerve impulses in muscles so that the muscles are better able to work.

Do NOT use Mestinon Controlled-Release Tablets if: you are allergic to any ingredient in Mestinon Controlled-Release Tablets you are taking quinine or quinidine you have a stomach, intestinal, or urinary blockage

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mestinon Controlled-Release Tablets:

Some medical conditions may interact with Mestinon Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have heart problems (eg, heart block, slow heartbeat), a urinary tract infection, asthma, or kidney problems

Some MEDICINES MAY INTERACT with Mestinon Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

Quinine or quinidine because effectiveness of Mestinon Controlled-Release Tablets may be decreased Succinylcholine because actions and side effects may be increased by Mestinon Controlled-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mestinon Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mestinon Controlled-Release Tablets:

Use Mestinon Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Mestinon Controlled-Release Tablets may be taken with or without food. Take with food if it upsets your stomach. Swallow Mestinon Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing. If you miss a dose of Mestinon Controlled-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Mestinon Controlled-Release Tablets.

Important safety information: Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Mestinon Controlled-Release Tablets. Use Mestinon Controlled-Release Tablets with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Mestinon Controlled-Release Tablets, discuss with your doctor the benefits and risks of using Mestinon Controlled-Release Tablets during pregnancy. Mestinon Controlled-Release Tablets are excreted in breast milk. If you are or will be breast-feeding while you are using Mestinon Controlled-Release Tablets, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Mestinon Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; fainting; increased production of saliva; increased sweating; muscle weakness; nausea; small pupils; stomach cramps; trouble breathing; vision changes; vomiting; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Mestinon side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fainting; increased production of saliva; increased sweating; muscle weakness; nausea; small pupils; stomach cramps; trouble breathing; vision changes; vomiting; weakness.

Proper storage of Mestinon Controlled-Release Tablets:

Store Mestinon Controlled-Release Tablets between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mestinon Controlled-Release Tablets out of the reach of children and away from pets.

General information: If you have any questions about Mestinon Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider. Mestinon Controlled-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Mestinon Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Mestinon resources Mestinon Side Effects (in more detail) Mestinon Use in Pregnancy & Breastfeeding Drug Images Mestinon Drug Interactions Mestinon Support Group 6 Reviews for Mestinon - Add your own review/rating Compare Mestinon with other medications Dysautonomia Myasthenia Gravis Nerve Agent Pretreatment Reversal of Nondepolarizing Muscle Relaxants
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Mestinon Timespan


Generic Name: pyridostigmine (py rid o STIG meen)
Brand Names: Mestinon, Mestinon Timespan

What is Mestinon Timespan (pyridostigmine)?

Pyridostigmine affects chemicals in the body that are involved in the communication between nerve impulses and muscle movement.

Pyridostigmine is used to treat the symptoms of myasthenia gravis. It is also used in military personnel who have been exposed to nerve gas.

Pyridostigmine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Mestinon Timespan (pyridostigmine)? You should not use pyridostigmine if you are allergic to it, or if you have a bladder or bowel obstruction.

Before taking pyridostigmine, tell your doctor if you have asthma, kidney disease, an ulcer or other serious stomach disorder, high blood pressure, heart disease, overactive thyroid, or a history of seizures.

The amount and timing of this medicine is extremely important to the success of your treatment. Carefully follow your doctor's instructions about how much medicine to take and when to take it.

This medication may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Your doctor may occasionally change your dose to make sure you get the best results. You may be asked to keep a daily record of when you took each dose and how long the effects lasted. This will help your doctor determine if your dose needs to be adjusted.

If you need surgery, tell the surgeon ahead of time that you are using pyridostigmine. You may need to stop using the medicine for a short time. What should I discuss with my health care provider before taking Mestinon Timespan (pyridostigmine)? You should not use pyridostigmine if you are allergic to it, or if you have a bladder or bowel obstruction.

To make sure you can safely take pyridostigmine, tell your doctor if you have any of these other conditions:

asthma;

kidney disease;

an ulcer or other serious stomach disorder;

high blood pressure, heart disease;

overactive thyroid; or

a history of seizures.

It is not known whether pyridostigmine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether pyridostigmine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Mestinon Timespan (pyridostigmine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medicine with food or milk if it upsets your stomach. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

The amount and timing of this medicine is extremely important to the success of your treatment. Carefully follow your doctor's instructions about how much medicine to take and when to take it.

Your doctor may occasionally change your dose to make sure you get the best results. You may be asked to keep a daily record of when you took each dose and how long the effects lasted. This will help your doctor determine if your dose needs to be adjusted.

If you need surgery, tell the surgeon ahead of time that you are using pyridostigmine. You may need to stop using the medicine for a short time. Store at room temperature away from moisture and heat.

Keep the tablets in their original container, along with the canister of moisture-absorbing preservative that comes with this medicine.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, diarrhea, stomach cramps, sweating, blurred vision, drooling, and weak or shallow breathing.

Worsening muscle weakness, or no change in your myasthenia gravis symptoms, may also be signs of overdose.

What should I avoid while taking Mestinon Timespan (pyridostigmine)? This medication may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of pyridostigmine. Mestinon Timespan (pyridostigmine) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using pyridostigmine and call your doctor at once if you have any of these serious side effects:

extreme muscle weakness, muscle twicthing;

slurred speech, vision problems;

severe vomiting or diarrhea;

cough with mucus;

confusion, anxiety, panic attacks;

seizure (convulsions); or

worsening or no improvement in your symptoms of myasthenia gravis.

Less serious side effects may include:

cold sweat, pale skin;

urinating more than usual;

watery eyes;

mild nausea, vomiting, or upset stomach;

warmth or tingly feeling; or

mild rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mestinon Timespan (pyridostigmine)?

Tell your doctor about all other medicines you use, especially:

atropine (Atreza, Sal-Tropine);

belladonna (Donnatal, and others);

benztropine (Cogentin);

clidinium (Quarzan);

clozapine (Clozaril, FazaClo);

dimenhydrinate (Dramamine);

methscopolamine (Pamine), scopolamine (Transderm Scop);

glycopyrrolate (Robinul);

mepenzolate (Cantil);

bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

cold medicine, allergy medicine, or sleeping pills that contain an antihistamine such as diphenhydramine (Tylenol PM) or doxylamine (Unisom);

heart rhythm medication such as quinidine (Quin-G), procainamide (Procan, Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others;

irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);

medicine to treat Alzheimer's dementia, such as donepezil (Aricept), rivastigmine (Exelon), or tacrine (Cognex); or

a steroid such as betamethasone (Celestone) or dexamethasone (Cortastat, Dexasone, Solurex, DexPak).

This list is not complete and other drugs may interact with pyridostigmine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Mestinon Timespan resources Mestinon Timespan Side Effects (in more detail) Mestinon Timespan Use in Pregnancy & Breastfeeding Drug Images Mestinon Timespan Drug Interactions Mestinon Timespan Support Group 1 Review for Mestinon Timespan - Add your own review/rating Pyridostigmine Prescribing Information (FDA) Mestinon MedFacts Consumer Leaflet (Wolters Kluwer) Mestinon Prescribing Information (FDA) Pyridostigmine Bromide Monograph (AHFS DI) Regonol Prescribing Information (FDA) Compare Mestinon Timespan with other medications Dysautonomia Myasthenia Gravis Nerve Agent Pretreatment Reversal of Nondepolarizing Muscle Relaxants Where can I get more information? Your pharmacist can provide more information about pyridostigmine.

See also: Mestinon Timespan side effects (in more detail)


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Nasal steroids


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Nasal corticosteroids are very effective in controlling allergic inflammation in the nose. Corticosteroids work on multiple cell types and mediators for example, mast cells, macrophages, leukotrienes and so on, to control inflammation. Nasal steroid sprays are usually first line treatment for nasal symptoms of hay fever or allergic rhinitis.

See also

Medical conditions associated with nasal steroids:

Hay Fever Nasal Polyps Nasal Polyps, Prevention Rhinitis Drug List: Nasacort-Aq-Spray Beconase-Aq-Spray Nasarel-Spray Flonase Rhinocort Nasacort Nasonex Veramyst Omnaris Allernaze Nasacort-Hfa Rhinocort Zetonna
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Osteogenesis Imperfecta Medications


Definition of Osteogenesis Imperfecta: Osteogenesis imperfecta is a condition causing extremely fragile bones. More...

Drugs associated with Osteogenesis Imperfecta

The following drugs and medications are in some way related to, or used in the treatment of Osteogenesis Imperfecta. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Osteogenesis Imperfecta

Medical Encyclopedia:

Osteogenesis imperfecta
Drug List: Fortical Miacalcin Miacalcin-Nasal
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Antidiuretic hormones


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Antidiuretic hormone, also known as vasopressin is a hormone released by the posterior pituitary. It is important mainly for its actions on the kidneys where it increases the re-absorption of water. Vasopressin is also a powerful vasoconstrictor. Its effects are through two types of receptors, V1 and V2.

Water retention is mediated through V2 receptors, occurs at low plasma concentrations of vasopressin and is due to activation of adenylate cyclase and increased cAMP production in the collecting ducts of the nephrons. It increases the permeability of the membrane to water.

Vasopressin causes contraction of smooth muscle, mainly in the cardiovascular system. Vasocontriction occurs by mediation of V1 receptors and requires higher concentrations if vasopressin.

See also

Medical conditions associated with antidiuretic hormones:

Abdominal Distension Prior to Abdominal X-ray Asystole Diabetes Insipidus Esophageal Varices with Bleeding Gastrointestinal Hemorrhage Hemophilia A Postoperative Gas Pains Primary Nocturnal Enuresis Ventricular Fibrillation Ventricular Tachycardia von Willebrand's Disease Drug List: Stimate-Spray Ddavp Ddavp-Nasal-Spray Ddavp-Rhinal-Tube-Nasal Minirin-Spray Pitressin
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Fortical


Generic Name: calcitonin nasal (kal si TOE nin)
Brand Names: Fortical, Miacalcin Nasal

What is calcitonin nasal?

Calcitonin is a man-made form of a hormone that occurs naturally in the thyroid gland.

Calcitonin nasal is used to treat osteoporosis in women who have been in menopause for at least 5 years.

Calcitonin nasal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about calcitonin nasal? To make sure you are not allergic to this medication, your doctor may perform an allergy skin test before your first dose of calcitonin nasal.

Before using calcitonin nasal, tell your doctor if you have any nasal or sinus problems such as nasal deformities, a chronic infection, or nasal pain.

Avoid using any other nasal sprays or medicines at the same time you use calcitonin nasal unless your doctor has told you to.

Call your doctor at once if you have any type of severe irritation of your nose, or if you feel light-headed or faint.

Less serious nasal irritation is more likely to occur, such as minor bleeding, redness, itching, tenderness, dryness, crusting, scabs, or nasal congestion.

To be sure this medication is not causing harmful side effects to the inside of your nose, your doctor may want to check your nasal passages often. Visit your doctor regularly.

What should I discuss with my healthcare provider before using calcitonin nasal? Do not use this medication if you are allergic to salmon calcitonin.

To make sure you can safely use calcitonin nasal, tell your doctor if you have any nasal or sinus problems such as nasal deformities, a chronic infection, or nasal pain.

FDA pregnancy category C. It is not known whether calcitonin nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether calcitonin nasal passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use calcitonin nasal?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

To make sure you are not allergic to this medication, your doctor may perform an allergy skin test before your first dose of calcitonin nasal.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Store unopened calcitonin nasal in the refrigerator but do not allow it to freeze. Once you put the bottle and pump assembly together, you may keep the medicine at room temperature, away from light and heat. Keep the bottle upright while stored. Throw away any unused medicine after 35 days.

Before your first use of the assembled bottle and pump, you must prime the spray. Allow the medicine to reach room temperature before priming.

To prime calcitonin nasal, spray the medicine into the air and away from your face, until a fine mist appears. You will need to prime the pump only before your first use of the newly assembled bottle.

Calcitonin nasal is usually given as one spray per day into only one of your nostrils. Use the other nostril the next day and continue alternating back and forth for each daily dose.

Before each use, gently blow your nose to clear your nostrils.

Hold the nasal spray upright with your first and second fingers on each side of the pump and your thumb on the bottom of the bottle.

Gently insert the sprayer tip into the nostril but not far into your nose. Bend your head forward to aim the spray toward the back of your nose. Pump the spray unit firmly to spray the medicine into your nostril. You do not need to sniff or inhale deeply.

Calcitonin nasal spray delivers a fine mist into the nose. Even if you do not feel the spray while using it, the medication is still being absorbed by your nasal passages.

Avoid blowing your nose for several minutes after using this medication.

Each bottle contains 30 doses of calcitonin nasal. Throw away the medicine after 30 uses, even if there is still medicine left in the bottle.

To be sure this medication is not causing harmful side effects to the inside of your nose, your doctor may want to check your nasal passages often. Visit your doctor regularly.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of calcitonin nasal is not likely to produce life-threatening side effects.

What should I avoid while using calcitonin nasal?

Avoid using any other nasal sprays or nasal medications at the same time you use calcitonin nasal unless your doctor has told you to.

Calcitonin nasal side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting; or

severe nasal irritation.

Less serious side effects may include:

bleeding from your nose;

runny or stuffy nose;

dryness, itching, tenderness, or general discomfort of your nose;

crusting, scabs, or sores inside your nose;

redness in or around your nose;

warmth, redness, or tingly feeling under your skin;

headache;

back pain; or

nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect calcitonin nasal?

There may be other drugs that can interact with calcitonin nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Fortical resources Fortical Side Effects (in more detail) Fortical Use in Pregnancy & Breastfeeding Fortical Drug Interactions Fortical Support Group 1 Review for Fortical - Add your own review/rating Compare Fortical with other medications Hypercalcemia Osteogenesis Imperfecta Osteoporosis Paget's Disease Where can I get more information? Your pharmacist can provide more information about calcitonin nasal.

See also: Fortical side effects (in more detail)


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Nasalcrom nasal


Generic Name: cromolyn sodium (nasal) (KRO mo lin SO dee um)
Brand Names: Nasalcrom

What is Nasalcrom (cromolyn sodium (nasal))?

Cromolyn sodium is an anti-inflammatory medication. It works by preventing the release of substances in the body that cause inflammation.

Cromolyn sodium nasal is used to prevent allergy symptoms such as runny nose, stuffy nose, sneezing, itching, and post-nasal drip.

Cromolyn sodium nasal will not treat allergy symptoms that have already begun. The medication works best if used at least 1 week before you come into contact with things you are allergic to (pollen, dust, pets, etc).

Cromolyn sodium nasal will not treat the symptoms of asthma, sinus infections, or the common cold.

Cromolyn sodium nasal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Nasalcrom (cromolyn sodium (nasal))? You should not use this medication if you are allergic to cromolyn sodium.

Before you use cromolyn sodium nasal, tell your doctor if you have asthma, drug allergies, or polyps in your nose.

Cromolyn sodium nasal will not treat allergy symptoms that have already begun. The medication works best if used at least 1 week before you come into contact with things you are allergic to (pollen, dust, pets, etc).

Stop using this medication and call your doctor if you have severe burning, stinging, or irritation in your nose, nosebleeds, sinus pain, sores in your nose, wheezing, chest tightness, fever, or green/yellow mucus from your nose.

Do not use cromolyn sodium nasal more than 6 times in a 24-hour period. Do not use this medication for longer than 12 weeks unless your doctor has told you to. What should I discuss with my healthcare provider before using Nasalcrom (cromolyn sodium (nasal))? You should not use this medication if you are allergic to cromolyn sodium.

To make sure you can safely use cromolyn sodium nasal, tell your doctor if you have any of these other conditions:

asthma;

drug allergies; or

polyps in your nose.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether cromolyn sodium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use Nasalcrom (cromolyn sodium (nasal))?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medicine is usually given as 1 spray into each nostril every 4 to 6 hours during allergy season or within 1 week before you will be exposed to an allergen. Follow your doctor's instructions.

Do not use cromolyn sodium nasal more than 6 times in a 24-hour period. Do not use this medication for longer than 12 weeks unless your doctor has told you to.

To use the nasal spray:

Blow your nose gently before each use.

Keeping your head upright, insert just the tip of the spray bottle into your nostril. Hold your other nostril closed with one finger. Spray the medicine into the nostril while inhaling, then sniff deeply a few times to make sure the medicine gets up into your nasal passages.

Repeat these steps in your other nostril.

After using the nasal spray, rinse the tip with hot water or wipe it with a clean tissue and recap. Avoid getting water into the nasal spray tip.

It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 2 weeks of treatment.

Store at room temperature away from moisture, heat, and light. Keep the bottle capped when not in use. What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using Nasalcrom (cromolyn sodium (nasal))? Avoid getting this medication in your eyes. If this does happen, rinse with water. Nasalcrom (cromolyn sodium (nasal)) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives or itching; difficulty breathing; severe dizziness; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor if you have any of these serious side effects:

severe burning, stinging, or irritation in your nose;

nosebleeds, sinus pain, or sores in your nose;

wheezing, tight feeling in your chest; or

fever, green or yellow mucus from the nose.

Less serious side effects may include mild burning or stinging inside your nose after use.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nasalcrom (cromolyn sodium (nasal))?

There may be other drugs that can interact with cromolyn sodium nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Nasalcrom resources Nasalcrom Side Effects (in more detail) Nasalcrom Use in Pregnancy & Breastfeeding Nasalcrom Support Group 0 Reviews for Nasalcrom - Add your own review/rating Compare Nasalcrom with other medications Hay Fever Where can I get more information? Your pharmacist can provide more information about cromolyn sodium nasal.

See also: Nasalcrom side effects (in more detail)


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NTZ Long Acting Nasal


Generic Name: oxymetazoline nasal (ox ee me TAZ oh leen)
Brand Names: Afrin, Afrin Nasal Sinus, Allerest 12 Hour Nasal Spray, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Neo-Synephrine 12 Hour, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex Long-Acting, Twice-A-Day

What is NTZ Long Acting Nasal (oxymetazoline nasal)?

Oxymetazoline is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. The nasal formulation acts directly on the blood vessels in your nasal tissues. Constriction of the blood vessels in your nose and sinuses leads to drainage of these areas and a decrease in congestion.

Oxymetazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.

Oxymetazoline nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about NTZ Long Acting Nasal (oxymetazoline nasal)?

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Do not use more of this medication than is recommended on the package or by your doctor. Who should not use NTZ Long Acting Nasal (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. This could cause a very dangerous drug interaction with serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure;

any type of heart disease, hardening of the arteries, or irregular heart beats;

thyroid problems;

diabetes;

glaucoma or increased pressure in the eye;

an enlarged prostate or difficulty urinating; or

liver or kidney disease.

You may not be able to use oxymetazoline nasal, or you may require a lower dose or special monitoring during your therapy if you have any of the conditions listed above.

It is not known whether oxymetazoline nasal will harm an unborn baby. Do not use oxymetazoline nasal without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of oxymetazoline nasal. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. If you over 60 years of age, you may be more likely to experience side effects from oxymetazoline nasal. You may require a lower dose of this medication. How should I use NTZ Long Acting Nasal (oxymetazoline nasal)?

Use oxymetazoline nasal exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To apply the nasal spray, keep your head upright, spray, then sniff hard for a few minutes after administering a dose.

To apply the nasal drops, lie on a bed on your back with your head hanging over the edge. Insert the drops and remain in this position for several minutes. Gently turn your head from side to side.

Do not allow the tip of the container to touch the inside of your nose or any other surface. This spreads the infection.

Also, to prevent the spread of infection, do not share this medication with anyone else.

Discard this medication bottle after use. Do not save it for reuse.

Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Oxymetazoline nasal should not be used more often than twice a day (every 12 hours).

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Store oxymetazoline nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of an oxymetazoline nasal overdose include extreme tiredness, sweating, dizziness, a slow heartbeat, and coma.

What should I avoid while taking NTZ Long Acting Nasal (oxymetazoline nasal)? Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. NTZ Long Acting Nasal (oxymetazoline nasal) side effects

If you experience any of the following serious side effects, stop using oxymetazoline nasal and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

seizures;

unusual behavior or hallucinations; or

an irregular or fast heartbeat.

More commonly, you may experience some sneezing or burning, stinging, dryness, or irritation of the nose. These side effects are usually mild and temporary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect NTZ Long Acting Nasal (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Although drug interactions between topical nasal decongestants and drugs taken by mouth are not expected, they can occur. Rarely, oxymetazoline nasal may interact with the following medicines:

furazolidone (Furoxone);

guanethidine (Ismelin);

indomethacin (Indocin);

methyldopa (Aldomet);

bromocriptine (Parlodel);

caffeine in cola, tea, coffee, chocolate and other products;

theophylline (Theo-Dur, Theochron, Theolair, others);

tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine); and other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine).

Drugs other than those listed here may also interact with oxymetazoline nasal. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More NTZ Long Acting Nasal resources NTZ Long Acting Nasal Side Effects (in more detail) NTZ Long Acting Nasal Use in Pregnancy & Breastfeeding NTZ Long Acting Nasal Drug Interactions NTZ Long Acting Nasal Support Group 0 Reviews for NTZ Long Acting Nasal - Add your own review/rating Afrin Advanced Consumer (Micromedex) - Includes Dosage Information Afrin Solution MedFacts Consumer Leaflet (Wolters Kluwer) Compare NTZ Long Acting Nasal with other medications Nasal Congestion Where can I get more information? Your pharmacist has additional information about oxymetazoline nasal written for health professionals that you may read.

See also: NTZ Long Acting Nasal side effects (in more detail)


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Allerest 12 Hour Nasal Spray


Generic Name: oxymetazoline nasal (ox ee me TAZ oh leen)
Brand Names: Afrin, Afrin Nasal Sinus, Allerest 12 Hour Nasal Spray, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Neo-Synephrine 12 Hour, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex Long-Acting, Twice-A-Day

What is Allerest 12 Hour Nasal Spray (oxymetazoline nasal)?

Oxymetazoline is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. The nasal formulation acts directly on the blood vessels in your nasal tissues. Constriction of the blood vessels in your nose and sinuses leads to drainage of these areas and a decrease in congestion.

Oxymetazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.

Oxymetazoline nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Allerest 12 Hour Nasal Spray (oxymetazoline nasal)?

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Do not use more of this medication than is recommended on the package or by your doctor. Who should not use Allerest 12 Hour Nasal Spray (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. This could cause a very dangerous drug interaction with serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure;

any type of heart disease, hardening of the arteries, or irregular heart beats;

thyroid problems;

diabetes;

glaucoma or increased pressure in the eye;

an enlarged prostate or difficulty urinating; or

liver or kidney disease.

You may not be able to use oxymetazoline nasal, or you may require a lower dose or special monitoring during your therapy if you have any of the conditions listed above.

It is not known whether oxymetazoline nasal will harm an unborn baby. Do not use oxymetazoline nasal without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of oxymetazoline nasal. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. If you over 60 years of age, you may be more likely to experience side effects from oxymetazoline nasal. You may require a lower dose of this medication. How should I use Allerest 12 Hour Nasal Spray (oxymetazoline nasal)?

Use oxymetazoline nasal exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To apply the nasal spray, keep your head upright, spray, then sniff hard for a few minutes after administering a dose.

To apply the nasal drops, lie on a bed on your back with your head hanging over the edge. Insert the drops and remain in this position for several minutes. Gently turn your head from side to side.

Do not allow the tip of the container to touch the inside of your nose or any other surface. This spreads the infection.

Also, to prevent the spread of infection, do not share this medication with anyone else.

Discard this medication bottle after use. Do not save it for reuse.

Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Oxymetazoline nasal should not be used more often than twice a day (every 12 hours).

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Store oxymetazoline nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of an oxymetazoline nasal overdose include extreme tiredness, sweating, dizziness, a slow heartbeat, and coma.

What should I avoid while taking Allerest 12 Hour Nasal Spray (oxymetazoline nasal)? Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Allerest 12 Hour Nasal Spray (oxymetazoline nasal) side effects

If you experience any of the following serious side effects, stop using oxymetazoline nasal and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

seizures;

unusual behavior or hallucinations; or

an irregular or fast heartbeat.

More commonly, you may experience some sneezing or burning, stinging, dryness, or irritation of the nose. These side effects are usually mild and temporary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Allerest 12 Hour Nasal Spray (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Although drug interactions between topical nasal decongestants and drugs taken by mouth are not expected, they can occur. Rarely, oxymetazoline nasal may interact with the following medicines:

furazolidone (Furoxone);

guanethidine (Ismelin);

indomethacin (Indocin);

methyldopa (Aldomet);

bromocriptine (Parlodel);

caffeine in cola, tea, coffee, chocolate and other products;

theophylline (Theo-Dur, Theochron, Theolair, others);

tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine); and other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine).

Drugs other than those listed here may also interact with oxymetazoline nasal. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Allerest 12 Hour Nasal Spray resources Allerest 12 Hour Nasal Spray Side Effects (in more detail) Allerest 12 Hour Nasal Spray Use in Pregnancy & Breastfeeding Allerest 12 Hour Nasal Spray Drug Interactions 0 Reviews for Allerest2 Hour Nasal - Add your own review/rating Afrin Advanced Consumer (Micromedex) - Includes Dosage Information Afrin Solution MedFacts Consumer Leaflet (Wolters Kluwer) Compare Allerest 12 Hour Nasal Spray with other medications Nasal Congestion Where can I get more information? Your pharmacist has additional information about oxymetazoline nasal written for health professionals that you may read.

See also: Allerest2 Hour Nasal side effects (in more detail)


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Synarel


Generic Name: nafarelin nasal (NAF a REL in)
Brand Names: Synarel

What is Synarel (nafarelin nasal)?

Nafarelin nasal is a man-made form of a protein that is like a hormone in the body that helps regulate the menstrual cycle, fertility, and sexual development during puberty.

Nafarelin nasal is used to treat precocious puberty in both male and female children. It is also used to treat endometriosis in women who are 18 years of age or older.

Nafarelin nasal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Synarel (nafarelin nasal)? Nafarelin nasal can harm an unborn baby or cause birth defects. Do not use nafarelin nasal if you are pregnant. You should not use this medication if you are allergic to nafarelin or similar medicines such as leuprolide (Lupron, Eligard, Viadur), goserelin (Zoladex), histrelin (Vantas), or triptorelin (Trelstar). If you are a woman, you should not use nafarelin nasal if you have abnormal vaginal bleeding that has not been checked by a doctor; or if you are pregnant or breast-feeding.

Before using nafarelin nasal, tell your doctor if you have polycystic ovary disease, low bone mineral density, a history of osteoporosis, sneezing or a stuffy nose, diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol, if you take steroids or seizure medication, if you smoke, or if you drink large amounts of alcohol.

Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

Call your doctor at once if you have heavy or continued menstrual bleeding, pelvic pain or swelling, increased thirst, increased urination, chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating or general ill feeling, sudden numbness or weakness, sudden severe headache, confusion, or problems with vision, speech, or balance. What should I discuss with my healthcare provider before using Synarel (nafarelin nasal)? You should not use this medication if you are allergic to nafarelin or similar medicines such as leuprolide (Lupron, Eligard, Viadur), goserelin (Zoladex), histrelin (Vantas), or triptorelin (Trelstar). If you are a woman, you should not use nafarelin nasal if you have:

abnormal vaginal bleeding that has not been checked by a doctor; or

if you are pregnant or breast-feeding.

To make sure you can safely use nafarelin nasal, tell your doctor if you have any of these other conditions:

diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol (especially in men);

polycystic ovary disease;

low bone mineral density;

a personal or family history of osteoporosis;

sneezing or a runny nose;

if you take steroids or seizure medication; or

if you smoke or drink large amounts of alcohol.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use nafarelin nasal if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

It is not known whether nafarelin nasal passes into breast milk or if it could harm a nursing baby. Do not breast-feed while using this medication. How should I use Synarel (nafarelin nasal)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

To use the nasal spray:

Before the first use, prime the spray bottle by pumping it 5 to 10 times until a fine spray appears.

Gently blow your nose to clear any mucus. Uncap the spray bottle.

Insert the tip of the spray bottle into your nostril, pointing it straight upward. Block your other nostril with your finger. Quickly and gently pump the spray bottle one time and sniff gently at the same time. Remove the pump from your nose and tilt your head back slightly for a few seconds.

If using more than one spray per nostril, wait at least 30 seconds between each spray.

Clean the spray bottle tip with a tissue and recap it.

To be sure this medication is helping your condition and is not causing harmful effects, your doctor will need to check your progress on a regular basis, especially during the first 6 to 8 weeks of treatment. Do not miss any scheduled appointments.

When you first start using nafarelin nasal to treat precocious puberty, you may notice an increase in signs of puberty, such as enlarged breasts or vaginal bleeding. These are normal side effects of this medication during the first month of use. If such pubertal signs continue for longer than 1 month, contact your doctor.

Use nafarelin nasal regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store at room temperature away from moisture, heat, and light. Keep the bottle upright when not in use. What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Synarel (nafarelin nasal)?

Try not to sneeze or blow your nose just after using the spray. This may decrease the amount of medication your body absorbs.

Synarel (nafarelin nasal) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

heavy or continued menstrual bleeding;

pelvic pain or swelling;

increased thirst, increased urination;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or

sudden numbness or weakness, sudden severe headache, confusion, problems with vision, speech, or balance.

Less serious side effects may include:

changes in breast size;

oily skin or acne, increased body odor;

dandruff;

increase in pubic hair growth;

mood changes;

runny nose;

hot flashes;

mild headache, muscle pain;

light and occasional menstrual bleeding;

white or brownish vaginal discharge;

vaginal dryness; or

changes in sexual desire.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Synarel (nafarelin nasal)?

If you have a stuffy nose during your treatment with nafarelin nasal, ask your doctor before using a decongestant. If your doctor recommends a decongestant nasal spray, do not use the decongestant for at least 2 hours after you have used nafarelin nasal.

There may be other drugs that can interact with nafarelin nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Synarel resources Synarel Side Effects (in more detail) Synarel Use in Pregnancy & Breastfeeding Synarel Support Group 2 Reviews for Synarel - Add your own review/rating Synarel Prescribing Information (FDA) Synarel Monograph (AHFS DI) Synarel Advanced Consumer (Micromedex) - Includes Dosage Information Synarel MedFacts Consumer Leaflet (Wolters Kluwer) Compare Synarel with other medications Endometriosis Precocious Puberty Where can I get more information? Your pharmacist can provide more information about nafarelin nasal.

See also: Synarel side effects (in more detail)


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Neo-Synephrine 12 Hour


Generic Name: oxymetazoline nasal (ox ee me TAZ oh leen)
Brand Names: Afrin, Afrin Nasal Sinus, Allerest 12 Hour Nasal Spray, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Neo-Synephrine 12 Hour, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex Long-Acting, Twice-A-Day

What is Neo-Synephrine 12 Hour (oxymetazoline nasal)?

Oxymetazoline is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. The nasal formulation acts directly on the blood vessels in your nasal tissues. Constriction of the blood vessels in your nose and sinuses leads to drainage of these areas and a decrease in congestion.

Oxymetazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.

Oxymetazoline nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Neo-Synephrine 12 Hour (oxymetazoline nasal)?

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Do not use more of this medication than is recommended on the package or by your doctor. Who should not use Neo-Synephrine 12 Hour (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. This could cause a very dangerous drug interaction with serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure;

any type of heart disease, hardening of the arteries, or irregular heart beats;

thyroid problems;

diabetes;

glaucoma or increased pressure in the eye;

an enlarged prostate or difficulty urinating; or

liver or kidney disease.

You may not be able to use oxymetazoline nasal, or you may require a lower dose or special monitoring during your therapy if you have any of the conditions listed above.

It is not known whether oxymetazoline nasal will harm an unborn baby. Do not use oxymetazoline nasal without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of oxymetazoline nasal. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. If you over 60 years of age, you may be more likely to experience side effects from oxymetazoline nasal. You may require a lower dose of this medication. How should I use Neo-Synephrine 12 Hour (oxymetazoline nasal)?

Use oxymetazoline nasal exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To apply the nasal spray, keep your head upright, spray, then sniff hard for a few minutes after administering a dose.

To apply the nasal drops, lie on a bed on your back with your head hanging over the edge. Insert the drops and remain in this position for several minutes. Gently turn your head from side to side.

Do not allow the tip of the container to touch the inside of your nose or any other surface. This spreads the infection.

Also, to prevent the spread of infection, do not share this medication with anyone else.

Discard this medication bottle after use. Do not save it for reuse.

Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Oxymetazoline nasal should not be used more often than twice a day (every 12 hours).

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Store oxymetazoline nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of an oxymetazoline nasal overdose include extreme tiredness, sweating, dizziness, a slow heartbeat, and coma.

What should I avoid while taking Neo-Synephrine 12 Hour (oxymetazoline nasal)? Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Neo-Synephrine 12 Hour (oxymetazoline nasal) side effects

If you experience any of the following serious side effects, stop using oxymetazoline nasal and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

seizures;

unusual behavior or hallucinations; or

an irregular or fast heartbeat.

More commonly, you may experience some sneezing or burning, stinging, dryness, or irritation of the nose. These side effects are usually mild and temporary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Neo-Synephrine 12 Hour (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Although drug interactions between topical nasal decongestants and drugs taken by mouth are not expected, they can occur. Rarely, oxymetazoline nasal may interact with the following medicines:

furazolidone (Furoxone);

guanethidine (Ismelin);

indomethacin (Indocin);

methyldopa (Aldomet);

bromocriptine (Parlodel);

caffeine in cola, tea, coffee, chocolate and other products;

theophylline (Theo-Dur, Theochron, Theolair, others);

tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine); and other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine).

Drugs other than those listed here may also interact with oxymetazoline nasal. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Neo-Synephrine 12 Hour resources Neo-Synephrine 12 Hour Side Effects (in more detail) Neo-Synephrine 12 Hour Use in Pregnancy & Breastfeeding Neo-Synephrine 12 Hour Drug Interactions Neo-Synephrine 12 Hour Support Group 0 Reviews for Neo-Synephrine2 Hour - Add your own review/rating Neo-Synephrine 12 Hour Advanced Consumer (Micromedex) - Includes Dosage Information Afrin Solution MedFacts Consumer Leaflet (Wolters Kluwer) Compare Neo-Synephrine 12 Hour with other medications Nasal Congestion Where can I get more information? Your pharmacist has additional information about oxymetazoline nasal written for health professionals that you may read.

See also: Neo-Synephrine2 Hour side effects (in more detail)


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Care Decongestant Nasal Spray


1. Name Of The Medicinal Product

Oxymetazoline 0.05% w/v Nasal Spray

Care Decongestant Nasal Spray

2. Qualitative And Quantitative Composition

The nasal solution contains Oxymetazoline (as hydrochloride) 0.05% w/v.

For excipients, see 6.1

3. Pharmaceutical Form

Nasal spray, solution

4. Clinical Particulars 4.1 Therapeutic Indications

Oxymetazoline Nasal Spray or Care Decongestant Nasal Spray is recommended for the relief of nasal congestion in such conditions as the common cold, catarrh and hayfever.

4.2 Posology And Method Of Administration

Adults and Elderly

While holding upright the spray nozzle should be inserted into each nostril in turn and squeezed firmly twice while breathing in. The application may be repeated up to 2 times a day, or used at bedtime to give relief through the night.

Children

Not recommended for children under 12 years of age.

4.3 Contraindications

Hypersensitivity to any component of the medicinal product.

Patients who are receiving monoamine oxidase inhibitors or within 14 days of stopping such treatment; patients suffering from porphyria, glaucoma, coronary artery disease, hypertension, hyperthyroidism or diabetes.

4.4 Special Warnings And Precautions For Use

If symptoms persist, consult your doctor. Prolonged use may result in rhinitis medicamentosa and should therefore be avoided. Treatment should be limited to a maximum of seven days. Keep all medicines safely away from children.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

If you are taking other medicines, you should see your doctor for advice before taking this medicine.

4.6 Pregnancy And Lactation

The safety to use in pregnancy has not been established and administration of oxymetazoline during pregnancy should be avoided.

4.7 Effects On Ability To Drive And Use Machines

None.

4.8 Undesirable Effects

This medicinal product contains thiomersal (an organomercuric compound) as a preservative and therefore, it is possible that it may cause local skin reactions (e.g. contact dermatitis) and discolouration.

Benzalkonium chloride may cause local skin irritation.

4.9 Overdose

No statement.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Pharmacotherapeutic group (ATC code): S01G A04 Sympathomimetics used as decongestants.

Oxymetazoline is an alpha-adrenoceptor agonist which causes local vasoconstriction when applied to nasal membrane.

5.2 Pharmacokinetic Properties

When applied locally to nasal mucosa, oxymetazoline acts within a few minutes and its effects last for up to 12 hours.

5.3 Preclinical Safety Data

There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC

6. Pharmaceutical Particulars 6.1 List Of Excipients

Benzalkonium chloride

Thiomersal

Sodium chloride

Levomenthol

Cineole

Camphor

Methyl salicylate

Poloxamer 188

Sodium citrate (dihydrate) (E331)

Citric acid (anhydrous) (E330)

Purified water

6.2 Incompatibilities

None

6.3 Shelf Life

2 years

6.4 Special Precautions For Storage

None

6.5 Nature And Contents Of Container

White, low density polyethylene/polyethylene copolymer 15ml bottle.

White, high density polyethylene 15ml and 20ml bottle.

6.6 Special Precautions For Disposal And Other Handling

None

7. Marketing Authorisation Holder

Thornton & Ross Ltd

Linthwaite

Huddersfield

West Yorkshire

HD7 5QH

United Kingdom

8. Marketing Authorisation Number(S)

PL 00240/0343

9. Date Of First Authorisation/Renewal Of The Authorisation

24/01/2007

10. Date Of Revision Of The Text

20/12/2010

11 DOSIMETRY (IF APPLICABLE)

Not Applicable

12 INSTRUCTIONS FOR PREPARATION OF RADIOPHARMACEUTICALS (IF APPLICABLE)

Not Applicable


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Xylometazoline Spray


Pronunciation: ZYE-loe-me-TAZ-oh-leen
Generic Name: Xylometazoline
Brand Name: 4-Way Moisturizing Relief
Xylometazoline Spray is used for:

Relieving nasal congestion due to the common cold, hay fever, other upper respiratory tract allergies, or sinus infection. It also soothes nasal discomfort caused by dryness. It may also be used to treat other conditions as determined by your doctor.

Xylometazoline Spray is a decongestant. It works by shrinking swollen and congested nasal tissues (mucous membranes) by constricting blood vessels. This results in relief of congestion (stuffy feeling), improved drainage of mucus, and improved breathing through the nose. Local application (eg, nose drops and sprays) causes more intense and rapid vasoconstriction than oral medicines (eg, tablets, syrups).

Do NOT use Xylometazoline Spray if: you are allergic to any ingredient in Xylometazoline Spray

Contact your doctor or health care provider right away if any of these apply to you.

Before using Xylometazoline Spray:

Some medical conditions may interact with Xylometazoline Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of high blood pressure, enlarged prostate or trouble urinating, diabetes, overactive thyroid, or heart disease

Some MEDICINES MAY INTERACT with Xylometazoline Spray. However, no specific interactions with Xylometazoline Spray are known at this time.

Ask your health care provider if Xylometazoline Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Xylometazoline Spray:

Use Xylometazoline Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

To use a nose spray, gently blow your nose. Sit down and tilt your head back slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breathe gently through the open nostril and squeeze the spray container. If you are using more than 1 spray, wait for 1 to 2 minutes between sprays. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination. If you miss a dose of Xylometazoline Spray and are using it regularly, use it as soon as possible. If it is much more than 1 hour since your missed dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Xylometazoline Spray.

Important safety information: Do not use Xylometazoline Spray for more than 3 days unless advised to do so by your health care provider. Frequent or long-term use of Xylometazoline Spray may cause nasal congestion to recur or worsen. Diabetes patients - Xylometazoline Spray may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Xylometazoline Spray should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Xylometazoline Spray while you are pregnant. It is not known if Xylometazoline Spray is found in breast milk. If you are or will be breast-feeding while you use Xylometazoline Spray, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Xylometazoline Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increase in nasal discharge; temporary burning, stinging or sneezing.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat; nervousness; severe or persistent headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Xylometazoline side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Xylometazoline Spray:

Store Xylometazoline Spray at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Xylometazoline Spray out of the reach of children and away from pets.

General information: If you have any questions about Xylometazoline Spray, please talk with your doctor, pharmacist, or other health care provider. Xylometazoline Spray is to be used only by the patient for whom it is prescribed. Do not share it with other due to increased risk of spreading infection. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Xylometazoline Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Xylometazoline resources Xylometazoline Side Effects (in more detail) Xylometazoline Use in Pregnancy & Breastfeeding Xylometazoline Drug Interactions Xylometazoline Support Group 4 Reviews for Xylometazoline - Add your own review/rating Compare Xylometazoline with other medications Nasal Congestion
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Vicks Sinex Decongestant Nasal Spray


1. Name Of The Medicinal Product

Vicks Sinex Decongestant Nasal Spray

2. Qualitative And Quantitative Composition

ACTIVE INGREDIENT

 

 

Percentage quantity

Specification

Oxymetazoline hydrochloride

0.050% w/v

Ph. Eur

3. Pharmaceutical Form

Non-pressurised, aqueous nasal spray solution.

4. Clinical Particulars 4.1 Therapeutic Indications

The symptomatic relief of congestion of the upper respiratory tract due to the common cold, hay fever and sinusitis.

4.2 Posology And Method Of Administration

Adults and children over 12 years:

1-2 sprays per nostril every 6-8 hours unless otherwise advised by your doctor.

Topical application as a nasal spray.

4.3 Contraindications

See your doctor for advice before taking this medicine if you suffer from high blood pressure, any heart complaint, diabetes, thyroid disease, hepatic or renal disorders.

4.4 Special Warnings And Precautions For Use

See your doctor if you feel worse or do not feel better after 7 days. Inform your doctor if you develop new symptoms.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

If you are taking other medicines, you should see your doctor for advice before taking this medicine.

4.6 Pregnancy And Lactation

Before using this medicine, obtain advice from your doctor if you intend to become pregnant, are pregnant or are breast-feeding.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

None known.

4.9 Overdose

4.9.1 Symptoms

No information.

4.9.2 Treatment of overdose

No information.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Oxymetazoline hydrochloride:

?-Adrenergic imidazoline derivative, providing localised nasal vasoconstriction.

5.2 Pharmacokinetic Properties

Not applicable. The product provides purely local action.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Menthol

Eucalyptol

Sodium citrate dihydrate

Tyloxapol

Citric acid anhydrous

Chlorhexidine digluconate

Benzalkonium chloride

Camphor

Disodium edetate

Sodium hydroxide

Purified water

6.2 Incompatibilities

None known.

6.3 Shelf Life

3 years.

6.4 Special Precautions For Storage

None.

6.5 Nature And Contents Of Container

15ml or 20ml polyethylene/polypropylene copolymer bottle with L. D polyethylene dip tube to spray orifice. Green polypropylene screw cap.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

Procter & Gamble (Health & Beauty Care) Limited

The Heights,

Brooklands,

Weybridge,

Surrey

KT13 0XP

8. Marketing Authorisation Number(S)

PL 0129/5011R

9. Date Of First Authorisation/Renewal Of The Authorisation

12th June 1990

10. Date Of Revision Of The Text

June 2009


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Fluticasone Spray


Pronunciation: floo-TIK-a-sone
Generic Name: Fluticasone
Brand Name: Flonase
Fluticasone Spray is used for:

Treatment of allergic and nonallergic nasal symptoms including congestion, sneezing, itching, and runny nose.

Fluticasone Spray is a corticosteroid. It works by reducing inflammatory reactions in the nasal airway in response to allergens and irritants in the air.

Do NOT use Fluticasone Spray if: you are allergic to any ingredient in Fluticasone Spray

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fluticasone Spray:

Some medical conditions may interact with Fluticasone Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines or other substances if you have recently experienced an ulcer of the nasal septum, nasal surgery, or nasal trauma if you have active or inactive tuberculosis or a positive skin test for tuberculosis if you have infections of the respiratory tract, untreated fungal or bacterial infections, parasitic or viral infections, measles, chickenpox, herpes simplex in or around the eye, or recently received a vaccination if you have diarrhea if you have glaucoma or cataracts

Some MEDICINES MAY INTERACT with Fluticasone Spray. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain medicines that act on the liver (eg, protease inhibitors [eg, ritonavir], ketoconazole) because they may increase the actions and the risk of Fluticasone Spray's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluticasone Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fluticasone Spray:

Use Fluticasone Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Fluticasone Spray. Talk to your pharmacist if you have questions about this information. Shake gently before each use. If needed, prime the spray pump according to the directions in the extra patient leaflet. To use a nose spray, gently blow your nose. Sit down and tilt your head forward slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breathe gently through the open nostril and squeeze the spray container. If you are using more than 1 spray, wait for 1 to 2 minutes between sprays. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination. Symptoms can start to improve as soon as 12 hours after you start using Fluticasone Spray, and should improve within a couple of days. The full benefit may not be achieved until you have used Fluticasone Spray for several days. If symptoms do not improve or if the condition worsens, contact your health care provider. Use Fluticasone Spray on a regular schedule to get the most benefit from it. Using Fluticasone Spray at the same time each day will help you remember to use it. Continue to use Fluticasone Spray even if you feel well. Do not miss any doses. If you miss a dose of Fluticasone Spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Fluticasone Spray.

Important safety information: Fluticasone Spray may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Fluticasone Spray with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Use caution if you switch from an oral steroid (eg, prednisone) to Fluticasone Spray. It may take several months for your body to make enough natural steroids to handle events that cause physical stress. Such events may include injury, surgery, infection, loss of blood electrolytes, or a sudden asthma attack. These may be severe and sometimes fatal. Contact your doctor right away if any of these events occur. You may need to take an oral steroid (eg, prednisone) again. Carry a card at all times that says you may need an oral steroid (eg, prednisone) if any of these events occur. Tell your doctor or dentist that you take Fluticasone Spray before you receive any medical or dental care, emergency care, or surgery. If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. Avoid spraying in the eyes. Fluticasone Spray should not be used in CHILDREN younger than 4 years old; safety and effectiveness in these children have not been confirmed. Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Fluticasone Spray. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fluticasone Spray while you are pregnant. It is not known if Fluticasone Spray is found in breast milk. If you are or will be breast-feeding while you use Fluticasone Spray, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Fluticasone Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; nasal irritation or burning; nausea; nosebleed; sore throat; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blurred vision or other vision changes; frequent, severe, or persistent nosebleeds or nasal irritation; loss of sense of smell or taste; shortness of breath; sores in the nose; unusual nasal discharge; voice changes; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Fluticasone Spray:

Store Fluticasone Spray between 39 and 86 degrees F (4 and 30 degrees C). Keep Fluticasone Spray out of the reach of children and away from pets.

General information: If you have any questions about Fluticasone Spray, please talk with your doctor, pharmacist, or other health care provider. Fluticasone Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fluticasone Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Fluticasone resources Fluticasone Use in Pregnancy & Breastfeeding Fluticasone Drug Interactions Fluticasone Support Group 29 Reviews for Fluticasone - Add your own review/rating Compare Fluticasone with other medications Hay Fever Nasal Polyps Rhinitis
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Otrivine Adult Nasal Spray


1. Name Of The Medicinal Product

Otrivine® Adult Nasal Spray

2. Qualitative And Quantitative Composition

Xylometazoline Hydrochloride 0.1% w/v

For excipients see section 6.1

3. Pharmaceutical Form

Nasal spray, solution

The spray is a clear, colourless solution

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of nasal congestion, perennial and allergic rhinitis (including hay fever), sinusitis.

4.2 Posology And Method Of Administration

Adults, children over 12 years and the elderly: One application in each nostril 2 or 3 times daily

Route of administration: Nasal use

4.3 Contraindications

Known hypersensitivity to Otrivine.

Patients with trans-sphenoidal hypophysectomy or surgery exposing the dura mater.

4.4 Special Warnings And Precautions For Use

Patients are advised not to take decongestants for more than seven consecutive days. Otrivine, like other preparations belonging to the same class of active substances, should be used only with caution in patients showing a strong reaction to sympathomimetic agents as evidenced by signs of insomnia, dizziness etc.

• Do not exceed the recommended dosage

• Decongestants should not be used for more than seven consecutive days. If symptoms persist consult your doctor

• If you are pregnant or taking other medicines or are under a doctor's care consult him before using Otrivine

• The adult spray should not be used for infants or children under 12 years

• Each Otrivine pack should be used by one person only to prevent any cross infection

• Some patients who have sensitive nasal passages may feel some local discomfort when applying nasal drops. Other side effects are very rare

• Keep medicines out of reach of children

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None

4.6 Pregnancy And Lactation

No foetal toxicity or fertility studies have been carried out in animals. In view of its potential systemic vasoconstrictor effect, it is advisable to take the precaution of not using Otrivine during pregnancy.

Label warning: If you are pregnant or taking any other medicines or are under a doctor's care, consult him before using Otrivine.

4.7 Effects On Ability To Drive And Use Machines

None

4.8 Undesirable Effects

The following side effects have occasionally been encountered: A burning sensation in the nose and throat, local irritation, nausea, headache, and dryness of the nasal mucosa.

Systemic cardiovascular effects have occurred, and this should be kept in mind when giving Otrivine to people with cardiovascular disease.

4.9 Overdose

No cases of overdosage in adults have yet been reported. In rare instances of accidental poisoning in children, the clinical picture has been marked chiefly by signs such as acceleration and irregularity of the pulse, elevated blood pressure, drowsiness, respiratory depression or irregularity. There is no specific treatment and appropriate supportive treatment should be initiated.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Otrivine Adult Nasal Spray is a sympathomimetic agent with marked alpha-adrenergic activity, and is intended for use in the nose. It constricts the nasal blood vessels, thereby decongesting the mucosa of the nose and neighbouring regions of the pharynx. This enables patients suffering from colds to breathe more easily through the nose. The effect of Otrivine Adult Nasal Spray begins within a few minutes and lasts for up to 10 hours. Otrivine Adult Nasal Spray is generally well tolerated and does not impair the function of ciliated epithelium.

In a double-blind, saline solution (Otrisal) controlled study in patients with common cold, the

decongestant effect of Otrivine was significantly superior (p<0.0001) to Otrisal saline solution based on rhinomanometry measurement at 1 hour after administration of the study drugs.

5.2 Pharmacokinetic Properties

Systemic absorption may occur following nasal application of xylometazoline hydrochloride solutions. It is not used systemically.

5.3 Preclinical Safety Data

There are no findings in the preclinical testing which are of relevance to the prescriber.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Benzalkonium chloride

Disodium phosphate dodecahydrate (Sodium phosphate)

Disodium edetate

Sodium dihydrogen phophate dihydrate (Sodium acid phosphate)

Sodium chloride

Purified water

6.2 Incompatibilities

None

6.3 Shelf Life

Unopened: 36 months

After the container is opened for the first time: 28 days

6.4 Special Precautions For Storage

Do not store above 25°C.

6.5 Nature And Contents Of Container

Bottle: Low density polyethylene

Cap: High density polyethylene

Spray valve and capillary: Low density polyethylene

Carton: Cardboard

Pack size: 10 ml

6.6 Special Precautions For Disposal And Other Handling

Keep all medicines out of the reach of children

7. Marketing Authorisation Holder

Novartis Consumer Health UK Limited

Wimblehurst Road

Horsham

West Sussex

RH12 5AB

Trading as: Novartis Consumer Health

8. Marketing Authorisation Number(S)

PL 00030/0116

9. Date Of First Authorisation/Renewal Of The Authorisation

Date of first authorisation: 1 October 1997

10. Date Of Revision Of The Text

22 December 2009.

Legal category: GSL


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antimyasthenic Oral, Parenteral


Class Name: antimyasthenic (Oral route, Parenteral route)

Commonly used brand name(s)

In the U.S.

Aricept Cognex Exelon Mestinon Mestinon Timespan Mytelase Chloride Prostigmin Bromide Razadyne Razadyne ER Razadyne IR

In Canada

Reminyl

Available Dosage Forms:

Tablet Syrup Tablet, Extended Release Capsule, Extended Release Solution Tablet, Disintegrating Capsule Uses For This Medicine

Antimyasthenics are given by mouth or by injection to treat myasthenia gravis. Neostigmine may also be given by injection as a test for myasthenia gravis. Sometimes neostigmine is given by injection to prevent or treat certain urinary tract or intestinal disorders. In addition, neostigmine or pyridostigmine may be given by injection as an antidote to certain types of muscle relaxants used in surgery.

These medicines are available only with your doctor's prescription.

Before Using This Medicine Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of antimyasthenics in children with use in other age groups, these medicines are not expected to cause different side effects or problems in children than they do in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is not much information comparing use of antimyasthenics in the elderly with use in other age groups, these medicines are not expected to cause different side effects or problems in older people than they do in younger adults.

Pregnancy

Antimyasthenics have not been reported to cause birth defects; however, muscle weakness has occurred temporarily in some newborn babies whose mothers took antimyasthenics during pregnancy.

Breast Feeding

Antimyasthenics have not been reported to cause problems in nursing babies.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Atropine Metoclopramide

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Succinylcholine Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

Intestinal blockage or Urinary tract blockage or Urinary tract infection—These medicines may make the condition worse. Proper Use of This Medicine

Your doctor may want you to take this medicine with food or milk to help lessen the chance of side effects. If you have any questions about how you should be taking this medicine, check with your doctor.

Take this medicine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

If you are taking this medicine for myasthenia gravis:

When you first begin taking this medicine, your doctor may want you to keep a daily record of: the time you take each dose. how long you feel better after taking each dose. how long you feel worse. any side effects that occur.

This is to help your doctor decide whether the dose of this medicine should be increased or decreased and how often the medicine should be taken in order for it to be most effective in your condition.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For ambenonium For oral dosage form (tablets): For myasthenia gravis: Adults and teenagers—At first, the dose is 5 milligrams (mg) three or four times per day. Then, if needed, the dose will be adjusted by your doctor. Children—The dose is based on body weight or size and must be determined by your doctor. The total daily dose is usually 300 micrograms (mcg) per kilogram (kg) (136 mcg per pound) of body weight or 10 mg per square meter of body surface area. This dose may be divided into three or four smaller doses. If needed, the total daily dose will be increased to 1.5 mg per kg (0.68 mg per pound) of body weight or 50 mg per square meter of body surface area. This dose may be divided into three or four smaller doses. For neostigmine For oral dosage form (tablets): For myasthenia gravis: Adults and teenagers—At first, the dose is 15 milligrams (mg) every three or four hours. Then, the dose is 150 mg taken over a twenty-four-hour period. Children—The dose is based on body weight or size and must be determined by your doctor. The total daily dose is usually 2 mg per kilogram (kg) (0.91 mg per pound) of body weight or 60 mg per square meter of body surface area. This dose may be divided into six to eight smaller doses. For injection dosage form: For myasthenia gravis: Adults and teenagers—The usual dose is 500 micrograms (mcg) injected into a muscle or under the skin. Children—The dose is based on body weight and must be determined by your doctor. It is usually 10 to 40 mcg per kg (4.5 to 18.2 mcg per pound) of body weight, injected into a muscle or under the skin, every two or three hours. For urinary tract or intestinal disorders: Adults and teenagers—The usual dose is 250 to 500 mcg, injected into a muscle or under the skin, as needed. Children—Use and dose must be determined by your doctor. For pyridostigmine For oral dosage forms (syrup and tablets): For myasthenia gravis: Adults and teenagers—At first, the dose is 30 to 60 milligrams (mg) every three or four hours. Then, the dose is 60 mg to 1.5 grams (usually 600 mg) per day. Children—The dose is based on body weight or size and must be determined by your doctor. The total daily dose is usually 7 mg per kilogram (kg) (3.2 mg per pound) of body weight or 200 mg per square meter of body surface area. This dose may be divided into five or six smaller doses. For long-acting oral dosage form (extended-release tablets): For myasthenia gravis: Adults and teenagers—The usual dose is 180 to 540 mg one or two times per day. Children—Dose must be determined by your doctor. For injection dosage form: For myasthenia gravis: Adults and teenagers—The usual dose is 2 mg, injected into a muscle or vein, every two or three hours. Children—The dose is based on body weight and must be determined by your doctor. It is usually 50 to 150 micrograms (mcg) per kg (22.7 to 68.1 mcg per pound) of body weight, injected into a muscle every four to six hours. Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Keep the syrup form of pyridostigmine from freezing.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Symptoms of overdose Blurred vision clumsiness or unsteadiness confusion convulsions (seizures) diarrhea (severe) increase in bronchial secretions or watering of mouth (excessive) increasing muscle weakness (especially in the arms, neck, shoulders, and tongue) muscle cramps or twitching nausea or vomiting (severe) shortness of breath, troubled breathing, wheezing, or tightness in chest slow heartbeat slurred speech stomach cramps or pain (severe) unusual irritability, nervousness, restlessness, or fear unusual tiredness or weakness

Check with your doctor as soon as possible if any of the following side effects occur:

Rare Redness, swelling, or pain at place of injection (for pyridostigmine injection only) skin rash (does not apply to ambenonium)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Diarrhea increased sweating increased watering of mouth nausea or vomiting stomach cramps or pain Less common Frequent urge to urinate increase in bronchial secretions unusually small pupils unusual watering of eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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Afrin Solution


Pronunciation: OX-ee-MET-azz-oh-leen
Generic Name: Oxymetazoline
Brand Name: Examples include Afrin and Nostrilla 12 Hour
Afrin Solution is used for:

Relieving nasal congestion due to the common cold, hay fever, other upper respiratory tract allergies, or sinus infection. It may also be used to treat other conditions as determined by your doctor.

Afrin Solution is a decongestant. It works by shrinking swollen and congested nasal tissues (mucous membranes) by constricting blood vessels. This results in relief of congestion (stuffy feeling), improved drainage of mucus, and improved breathing through the nose. Local application (eg, nose drops and sprays) causes more intense and rapid vasoconstriction than oral medicines (eg, tablets, syrups).

Do NOT use Afrin Solution if: you are allergic to any ingredient in Afrin Solution you are also taking furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Afrin Solution:

Some medical conditions may interact with Afrin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have high blood pressure, enlarged prostate, diabetes, overactive thyroid, or heart disease

Some MEDICINES MAY INTERACT with Afrin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

Tricyclic antidepressants (eg, amitriptyline) because the effectiveness of Afrin Solution may be decreased Cocaine, furazolidone, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because side effects, such as headache, fever, or high blood pressure, may be increased Bromocriptine or cocaine because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Afrin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Afrin Solution:

Use Afrin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

To use nose drops, gently blow your nose. Lie down and tilt your head back. Breathe through your mouth. Insert the dropper tip in the nose no more than 1/3 inch. Try not to touch the dropper tip to the inside of your nose. Place the correct number of drops in your nose. Continue to lie down with your head tilted back for 2 minutes. To use a nose spray, gently blow your nose. Sit down and tilt your head back slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breathe gently through the open nostril and squeeze the spray container. If you are using more than 1 spray, wait for 1 to 2 minutes between sprays. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination. If you miss a dose of Afrin Solution and are using it regularly, use it as soon as possible. If it is much more than 1 hour since your missed dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Afrin Solution.

Important safety information: Do not use Afrin Solution for more than 3 days unless advised to do so by your health care provider. Frequent or long-term use of Afrin Solution may cause nasal congestion to recur or worsen. Do not share Afrin Solution with anyone else; this may cause the infection to spread. Diabetes patients - Afrin Solution may affect your blood sugar level. Your doctor may need to change the amount of diabetes medicine you are taking. Afrin Solution is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Afrin Solution during pregnancy. It is unknown if Afrin Solution is excreted in breast milk. If you are or will be breast-feeding while you are using Afrin Solution, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Afrin Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increase in nasal discharge; sneezing; stinging; temporary burning.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Afrin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Afrin Solution:

Store Afrin Solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in a tightly-closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Afrin Solution out of the reach of children and away from pets.

General information: If you have any questions about Afrin Solution, please talk with your doctor, pharmacist, or other health care provider. Afrin Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Afrin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Afrin resources Afrin Side Effects (in more detail) Afrin Use in Pregnancy & Breastfeeding Afrin Drug Interactions Afrin Support Group 1 Review for Afrin - Add your own review/rating Compare Afrin with other medications Nasal Congestion
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Pyridostigmine Tablets


Pronunciation: peer-id-oh-STIG-meen
Generic Name: Pyridostigmine
Brand Name: Mestinon
Pyridostigmine is used for:

Treating myasthenia gravis. It may also be used for other conditions as determined by your doctor.

Pyridostigmine is a cholinesterase inhibitor. It works by improving nerve impulses in muscles so that the muscles are better able to work.

Do NOT use Pyridostigmine if: you are allergic to any ingredient in Pyridostigmine you are taking quinine or quinidine you have a stomach, intestinal, or urinary blockage

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pyridostigmine:

Some medical conditions may interact with Pyridostigmine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have heart problems (eg, heart block, slow heartbeat), a urinary tract infection, asthma, or kidney problems

Some MEDICINES MAY INTERACT with Pyridostigmine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Quinine or quinidine because effectiveness of Pyridostigmine may be decreased Succinylcholine because actions and side effects may be increased by Pyridostigmine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pyridostigmine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pyridostigmine:

Use Pyridostigmine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pyridostigmine may be taken with or without food. Take with food if it upsets your stomach. If you miss a dose of Pyridostigmine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pyridostigmine.

Important safety information: Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Pyridostigmine. Use Pyridostigmine with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Pyridostigmine, discuss with your doctor the benefits and risks of using Pyridostigmine during pregnancy. Pyridostigmine is excreted in breast milk. If you are or will be breast-feeding while you are using Pyridostigmine, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Pyridostigmine:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; fainting; increased production of saliva; increased sweating; muscle weakness; nausea; small pupils; stomach cramps; trouble breathing; vision changes; vomiting; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pyridostigmine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fainting; increased production of saliva; increased sweating; muscle weakness; nausea; small pupils; stomach cramps; trouble breathing; vision changes; vomiting; weakness.

Proper storage of Pyridostigmine:

Store Pyridostigmine between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pyridostigmine out of the reach of children and away from pets.

General information: If you have any questions about Pyridostigmine, please talk with your doctor, pharmacist, or other health care provider. Pyridostigmine is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pyridostigmine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Pyridostigmine resources Pyridostigmine Side Effects (in more detail) Pyridostigmine Dosage Pyridostigmine Use in Pregnancy & Breastfeeding Drug Images Pyridostigmine Drug Interactions Pyridostigmine Support Group 12 Reviews for Pyridostigmine - Add your own review/rating Compare Pyridostigmine with other medications Dysautonomia Myasthenia Gravis Nerve Agent Pretreatment Reversal of Nondepolarizing Muscle Relaxants
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