1. Name Of The Medicinal Product

Praxilene 100mg Capsules

2. Qualitative And Quantitative Composition

100mg naftidrofuryl oxalate equivalent to 81.0 mg naftidrofuryl and 19.0 mg oxalate.

3. Pharmaceutical Form

Capsule

4. Clinical Particulars 4.1 Therapeutic Indications

Peripheral vascular disorders - intermittent claudication, night cramps, rest pain, incipient gangrene, trophic ulcers, Raynaud's Syndrome, diabetic arteriopathy and acrocyanosis.

Cerebral vascular disorders - cerebral insufficiency and cerebral atherosclerosis, particularly where these manifest themselves as mental deterioration and confusion in the elderly.

4.2 Posology And Method Of Administration

Peripheral vascular disorders - one or two capsules three times daily for a minimum of three months, or at the discretion of the physician.

Cerebral vascular disorders - one 100mg capsule three times daily for a minimum of three months, or at the discretion of the physician.

There is no recommended use for children.

Administration:

For oral administration. The capsules should be swallowed whole during meals with a sufficient amount of water (minimum) of one glass.

4.3 Contraindications

Hypersensitivity to the drug. Patients with a history of hyperoxaluria or recurrent calcium-containing stones.

4.4 Special Warnings And Precautions For Use

A sufficient amount of liquid should be taken during treatment to maintain an adequate level of diuresis.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

Pregnancy: There is no, or inadequate, evidence of the safety of naftidrofuryl oxalate in human pregnancy, but it has been in wide use for many years without apparent ill consequence, animal studies having shown no hazard. If drug therapy is needed in pregnancy, this drug can be used if there is no safer alternative.

Lactation: No information is available.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Naftidrofuryl oxalate is normally well tolerated in the dosage recommended. Occasionally nausea, epigastric pain and rashes have been noted.

Rarely, hepatitis has been reported. Very rarely, calcium oxalate kidney stones have been reported.

4.9 Overdose

Signs and symptoms: Depression of cardiac conduction and convulsions may occur.

Treatment: The stomach should be emptied by gastric lavage and emesis. Activated charcoal may be employed if necessary. Cardiovascular function and respiration should be monitored and, in severe cases, electrical pacemaking or the use of isoprenaline should be considered. Convulsions may be managed by diazepam.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Naftidrofuryl oxalate has been shown to exert a direct effect on intracellular metabolism. Thus it has been shown in man and animals that it produces an increase of ATP levels and a decrease of lactic acid levels in ischaemic conditions, evidence for an enhancement of cellular oxidative capacity. Furthermore, naftidrofuryl oxalate is a powerful spasmolytic agent.

5.2 Pharmacokinetic Properties

Naftidrofuryl oxalate is well absorbed when given orally. Peak plasma levels occur about 30 minutes after dosing and the half life is about an hour, although inter subject variation is relatively high. Accumulation does not occur at a dose level of 200mg three times daily.

The drug becomes extensively bound to plasma proteins and is excreted principally via the urine, all in the form of metabolites.

5.3 Preclinical Safety Data

No toxic effects were seen in animal studies which provide additional information to that obtained in man. In repeated dose studies the no effect level was 25mg/kg/day or greater. There was no evidence of effects on reproduction below doses which caused maternal toxicity.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Talc

Magnesium Stearate

Purified Water*

Denatured Ethanol*

Capsule Shells:

Erythrosine (E127)

Titanium Dioxide (E171)

Gelatine

Printing ink:

Black iron oxide (E172)

*Not present in final product

6.2 Incompatibilities

None known.

6.3 Shelf Life

36 months.

6.4 Special Precautions For Storage

Store below 20°C in a dry place away from light.

6.5 Nature And Contents Of Container

Pack size 10 (medical sample), 21 and 84 capsules:-

Cardboard carton containing blister strips comprising heat-sealable PVC (250?m) and aluminium foil (30?m).

Pack size 100 and 500:

Polyethylene securitainers with tamper evident closures.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Merck Serono Ltd

Bedfont Cross

Stanwell Road

Feltham

Middlesex

TW14 8NX, UK

8. Marketing Authorisation Number(S)

PL 11648/0064

9. Date Of First Authorisation/Renewal Of The Authorisation

24 March 2009

10. Date Of Revision Of The Text

24 March 2009



Pronunciation: PEN-i-SIL-in V poe-TAS-ee-um



Generic Name: propoxyphene and acetaminophen (Oral route)

a-seet-a-MIN-oh-fen, proe-POX-i-feen NAP-si-late

Oral route(Tablet)

Accidental and intentional overdose with propoxyphene products either alone or in combination with other CNS depressants, including alcohol, has occurred, and may be fatal within the first hour. Many of the fatalities have occurred in patients with previous histories of emotional disturbances or suicidal ideation/attempts and/or concomitant administration of sedatives, tranquilizers, muscle relaxants, antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene for patients who are suicidal or have a history of suicidal ideation. The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors leading to enhanced propoxyphene plasma levels; monitor patients closely and adjust dosages if necessary in patients receiving any CYP3A4 inhibitor concomitantly .

Commonly used brand name(s)

In the U.S.

Balacet 325 Darvocet A500 Darvocet-N 100 Darvocet-N 50 Pronap-100 Propoxacet-N Propoxacet-N 100

Available Dosage Forms:

Tablet

Therapeutic Class: Opioid/Acetaminophen Combination

Chemical Class: Propoxyphene

Uses For Pronap-100

Propoxyphene and acetaminophen combination is used to relieve mild to moderate pain. Propoxyphene belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

When propoxyphene is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

Products containing propoxyphene were withdrawn from the U.S. market starting November 19, 2010.

This medicine was available only with your doctor's prescription.

Before Using Pronap-100

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propoxyphene and acetaminophen combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propoxyphene and acetaminophen combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propoxyphene and acetaminophen combination.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Naltrexone Rasagiline Selegiline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adinazolam Alfentanil Alprazolam Amobarbital Anileridine Aprobarbital Bromazepam Brotizolam Buprenorphine Butabarbital Butalbital Butorphanol Carbamazepine Carisoprodol Chloral Hydrate Chlordiazepoxide Chlorzoxazone Clobazam Clonazepam Clorazepate Codeine Dantrolene Dezocine Diazepam Estazolam Ethchlorvynol Fentanyl Flunitrazepam Flurazepam Fospropofol Halazepam Hydrocodone Hydromorphone Ketazolam Levorphanol Lorazepam Lormetazepam Medazepam Meperidine Mephenesin Mephobarbital Meprobamate Metaxalone Methocarbamol Methohexital Midazolam Morphine Morphine Sulfate Liposome Nalbuphine Nitrazepam Nordazepam Opium Oxazepam Oxycodone Oxymorphone Pentazocine Pentobarbital Phenobarbital Prazepam Propoxyphene Quazepam Remifentanil Secobarbital Sodium Oxybate Sufentanil Tapentadol Temazepam Thiopental Triazolam

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol Carbamazepine Doxepin Isoniazid Metoprolol Phenytoin Propranolol Warfarin Zidovudine Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Cabbage Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Alcohol abuse, or history of or Brain tumor, history of or Chronic obstructive pulmonary disease (COPD) or Cor pulmonale (serious heart condition) or Drug dependence, especially with narcotics, or history of or Gallbladder disease or gallstones or Head injuries, history of or Hypovolemia (low blood volume)—Use with caution. May increase risk for more serious side effects. Asthma, severe or Breathing problems, severe (e.g., hypoxia) or Paralytic ileus (intestine stops working and may be blocked) or Respiratory depression (very slow breathing) or Suicidal ideation (thoughts of hurting or killing oneself), history of—Should not be used in patients with these conditions. Hypotension (low blood pressure) or Pancreatitis (inflammation of the pancreas)—Use with caution. May make these conditions worse. Kidney disease or Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of propoxyphene and acetaminophen

This section provides information on the proper use of a number of products that contain propoxyphene and acetaminophen. It may not be specific to Pronap-100. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence). Liver damage can occur if large amounts of acetaminophen are taken for a long time.

This combination medicine contains acetaminophen (Tylenol®). Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For mild to moderate pain: Adults—One or two tablets every 4 hours as needed. Your doctor may adjust your dose if needed. However, the dose is usually not more than 6 to 12 tablets per day. Children—Use and dose must be determined by your doctor. Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw any unused medicine by mixing it with used coffee grounds or kitty litter and place it in a sealable bag, empty can, or container.

Precautions While Using Pronap-100

It is very important that your doctor check your progress while you are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Talk to your doctor first before you stop taking this medicine and changing to another pain medicine.

This medicine can cause changes in heart rhythms, such as conditions called PR, QRS, and QT prolongation. It may change the way your heart beats and cause fainting, dizziness, lightheadedness, or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of the medicines listed above while you are using this medicine.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.

This medicine may make you dizzy, drowsy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

If you have been using this medicine regularly for several weeks or longer, do not change your dose or suddenly stop using it without checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

Using this medicine while you are pregnant may cause serious unwanted effects in your newborn baby. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Pronap-100 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Abdominal or stomach pain chills clay-colored stools dark urine dizziness fever headache itching loss of appetite nausea rash unpleasant breath odor unusual tiredness or weakness vomiting of blood yellow eyes or skin Incidence not known Bloating bloody or black, tarry stools bloody or cloudy urine change in consciousness chest pain or discomfort confusion cough decreased urine output difficult or troubled breathing dilated neck veins drowsiness extreme fatigue fainting fast, slow, pounding, or irregular heartbeat or pulse fever with or without chills general feeling of discomfort or illness hives hoarseness irregular, fast, slow, or shallow breathing itching joint pain, stiffness, or swelling light-colored stools loss of consciousness low blood pressure or pulse muscle aches and pains muscle tremors pain or discomfort in the arms, jaw, back, or neck pains in the stomach, side, or abdomen, possibly radiating to the back pale or blue lips, fingernails, or skin rapid, deep breathing redness of the skin restlessness right upper stomach pain and fullness runny nose severe stomach pain shakiness and unsteady walk shivering shortness of breath sore throat stomach cramps sudden decrease in the amount of urine sweating swelling of the eyelids, face, fingers, lips, hands, lower legs, or feet thoughts of suicide tightness in the chest trouble sleeping troubled breathing or swallowing unconsciousness unsteadiness, trembling, or other problems with muscle control or coordination very slow breathing very slow heartbeat vomiting of blood or material that looks like coffee grounds weight gain wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose Agitation bluish color of the fingernails, lips, skin, palms, or nail beds convulsion coughing that sometimes produces a pink frothy sputum decreased awareness or responsiveness depression difficult, fast, or noisy breathing, sometimes with wheezing dilated pupils hostility increased sweating irritability lethargy muscle tremors muscle twitching pale skin pounding or rapid pulse rapid weight gain rapid, deep breathing severe sleepiness sleepiness or unusual drowsiness slow to respond slurred speech weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Relaxed and calm feeling Incidence not known Abnormal behavior blurred or loss of vision constipation diarrhea disturbed color perception double vision false or unusual sense of well-being halos around lights indigestion muscular pain, tenderness, wasting, or weakness night blindness nightmares or unusually vivid dreams overbright appearance of lights seeing, hearing, or feeling things that are not there swelling of the eye tunnel vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Pronap-100 side effects (in more detail)

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More Pronap-100 resources Pronap-100 Side Effects (in more detail) Pronap-100 Use in Pregnancy & Breastfeeding Drug Images Pronap-100 Drug Interactions Pronap-100 Support Group 77 Reviews for Pronap-100 - Add your own review/rating Compare Pronap-100 with other medications Osteoarthritis Pain



Generic Name: sulfacetamide sodium and sulfur topical (SUL fa SEET a mide SOE dee um and SUL fur TOP i kal)



benzoyl peroxide



Pronunciation: pem-EER-oh-last



Pronunciation: NEE-oh-MYE-sin/POL-ee-MIX-in/pred-NIS-oh-lone



PROTELOS 2g

granules for oral suspension

Strontium ranelate

Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or your pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or your pharmacist. In this leaflet: 1. What PROTELOS is and what it is used for 2. Before you take PROTELOS 3. How to take PROTELOS 4. Possible side effects 5. How to store PROTELOS 6. Further information What Protelos Is And What It Is Used For

PROTELOS is a non-hormonal medicine used to treat osteoporosis in postmenopausal women. PROTELOS reduces the risk of fracture at the spine and at the hip.

About osteoporosis

Your body is constantly breaking down old bone and making new bone tissue. If you have osteoporosis, your body breaks down more bone than it forms so that gradually bone loss occurs and your bones become thinner and fragile. This is especially common in women after the menopause

Many people with osteoporosis have no symptoms and you may not even know that you have it. However, osteoporosis makes you more likely to have fractures (break bones), especially in your spine, hips and wrists.

How PROTELOS works

PROTELOS, which contains the substance strontium ranelate, belongs to a group of medicines used to treat bone diseases.

PROTELOS works by reducing bone breakdown and stimulating rebuilding of bone and therefore reduces the risk of fracture. The newly formed bone is of normal quality.

Before You Take Protelos Do not take PROTELOS: if you are allergic (hypersensitive) to strontium ranelate or any of the other ingredients of PROTELOS. Take special care with PROTELOS:

Before taking PROTELOS talk to your doctor:

if you have severe kidney disease. if you are being treated or have been treated for blood clots. if you are confined to bed or if you are to undergo an operation.



Pronunciation: peg-VI-soe-mant



Pronunciation: KAR-bin-OX-a-meen/METH-skoe-POL-a-meen/SOO-doe-e-FED-rin



per-FLOO-tren LIP-id MYE-kroe-sfeers

Commonly used brand name(s)

In the U.S.

Definity

Available Dosage Forms:

Suspension

Therapeutic Class: Radiological Non-Ionic Contrast Media

Uses For perflutren lipid microsphere

Perflutren lipid microsphere preparation is an ultrasound contrast agent. Ultrasound contrast agents are used to help provide a clear picture during ultrasound. Ultrasound is a special kind of diagnostic procedure. It uses high-frequency sound waves to create images or “pictures” of certain areas inside the body. The sound waves produced by the ultrasound equipment can be reflected (bounced off) by different parts of the body, like for example, the heart. As the sound waves return they are electronically converted into images on a television screen. Unlike x-rays, ultrasound does not involve ionizing radiation.

The perflutren lipid microspheres preparation contains very small gas-filled lipid microspheres that reflect the sound waves and help create a better picture. The lipid microsphere preparation is given by injection into a vein before ultrasound to help diagnose problems of the heart.

perflutren lipid microsphere is to be given only by or under the direct supervision of a doctor with specialized training in ultrasound procedures.

Before Using perflutren lipid microsphere

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to perflutren lipid microsphere or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of perflutren lipid microsphere injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of perflutren lipid microsphere injection in the elderly.

Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this diagnostic test with any of the following medicines is not recommended. Your doctor may decide not to use this diagnostic test or change some of the other medicines you take.

Cisapride Dronedarone Mesoridazine Pimozide Sparfloxacin Thioridazine

Receiving this diagnostic test with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alfuzosin Amiodarone Amitriptyline Amoxapine Apomorphine Arsenic Trioxide Asenapine Astemizole Azithromycin Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Crizotinib Dasatinib Desipramine Disopyramide Dofetilide Dolasetron Droperidol Erythromycin Flecainide Fluconazole Gatifloxacin Gemifloxacin Granisetron Halofantrine Haloperidol Ibutilide Iloperidone Imipramine Lapatinib Levofloxacin Lopinavir Lumefantrine Mefloquine Methadone Moxifloxacin Nilotinib Norfloxacin Nortriptyline Octreotide Ofloxacin Ondansetron Paliperidone Pazopanib Posaconazole Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Ranolazine Salmeterol Saquinavir Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Sunitinib Telavancin Telithromycin Terfenadine Tetrabenazine Toremifene Trazodone Trifluoperazine Trimipramine Vandetanib Vardenafil Vemurafenib Voriconazole Ziprasidone Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

Congestive heart failure or Heart attack or Heart disease (e.g., coronary artery syndrome) or Heart rhythm problems (e.g., ventricular arrhythmia) or Respiratory distress syndrome—May increase risk for more serious side effects. Heart rhythm problems (e.g., QT prolongation)—Use with caution. May make this condition worse. Heart shunt, right-to-left, bi-directional, or transient right-to-left—Should not be used in patients with this condition. Proper Use of perflutren lipid microsphere

A doctor or other trained health professional will give you perflutren lipid microsphere. perflutren lipid microsphere is given through a needle placed in one of your veins before ultrasound.

Your doctor may have special instructions for you in preparation for your test. If you do not understand the instructions you receive or if you have not received such instructions, check with your doctor in advance.

Precautions While Using perflutren lipid microsphere

It is very important that your doctor check your progress very closely while you are receiving perflutren lipid microsphere. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

perflutren lipid microsphere may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after receiving perflutren lipid microsphere.

Tell your doctor right away if you have a chest pain; fast, slow, pounding, or irregular heartbeat; lightheadedness, dizziness, or fainting; shortness of breath; or troubled breathing. These may be symptoms of heart or lung problems.

perflutren lipid microsphere Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare Black, tarry stools blurred vision chest pain chills difficulty with breathing dizziness, severe or continuing fast, pounding, or irregular heartbeat or pulse hives itching lightheadedness when getting up from a lying or sitting position shortness of breath skin rash slow or irregular heartbeat swollen glands unusual bleeding or bruising Incidence not known Cough difficulty swallowing dizziness puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue tightness in the chest unusual tiredness or weakness wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common Back pain feeling of warmth on the skin headache nausea redness of the face, neck, arms, and occasionally, upper chest Rare Acid or sour stomach bruising diarrhea difficulty with moving dizziness dryness of the mouth feeling of constant movement of self or surroundings fever heartburn indigestion leg cramps muscle stiffness or tension pain at the injection site pain or swelling in the joints prickly or tingling sensation sneezing or runny nose stomach upset or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More perflutren lipid microsphere Intravenous resources Perflutren lipid microsphere Intravenous Use in Pregnancy & Breastfeeding Perflutren lipid microsphere Intravenous Drug Interactions Perflutren lipid microsphere Intravenous Support Group 0 Reviews · Be the first to review/rate this drug



Generic Name: pantoprazole (Intravenous route)

pan-TOE-pra-zole

Commonly used brand name(s)

In the U.S.

Protonix Protonix IV

Available Dosage Forms:

Powder for Solution

Pharmacologic Class: Proton Pump Inhibitor

Uses For Protonix

Pantoprazole injection is used to treat certain conditions in which there is too much acid in the stomach. It is used for short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) with a history of erosive esophagitis. GERD is a condition in which the acid in the stomach washes back up into the esophagus. This medicine may also be used to treat Zollinger-Ellison syndrome or other conditions (e.g., cancer) in which the stomach produces too much acid.

Pantoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

Before Using Protonix

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pantoprazole injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pantoprazole injection in the elderly.

Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Atazanavir Citalopram Dasatinib Erlotinib Methotrexate Mycophenolate Mofetil Nelfinavir Nilotinib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cranberry Itraconazole Warfarin Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body. Osteoporosis (bone problem) or Zinc deficiency—Use with caution. May make these conditions worse. Proper Use of pantoprazole

This section provides information on the proper use of a number of products that contain pantoprazole. It may not be specific to Protonix. Please read with care.

A nurse or other trained health professional will give you this medicine in a clinic or hospital. This medicine is given through a needle placed in one of your veins.

It may take several days before this medicine begins to relieve stomach pain. To help relieve this pain, antacids may be taken with pantoprazole, unless your doctor has told you not to use them.

Tell your doctor if you have had problems with a lack of zinc in your body. Your doctor may want you to take zinc supplements.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using Protonix

It is important that your doctor check your progress at regular visits. If your condition does not improve, or if it becomes worse, check with your doctor.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive the medicine.

This medicine may cause thrombophlebitis. Check with your doctor right away if you notice any of these side effects at the injection site: changes in skin color, pain, tenderness, or swelling of the foot or leg.

Pantoprazole injection may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of this medicine, or use it for one year or more.

Do not stop using this medicine without first checking with your doctor, or unless told to do so by your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (e.g., atazanavir, Reyataz®) or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Protonix Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common Accumulation of pus bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site changes in skin color, pain, tenderness, or swelling of the foot or leg fever stomach pain swollen, red, tender area of infection Incidence not known Abdominal or stomach pain absence of or decrease in body movement blindness blistering, peeling, or loosening of the skin bloating of abdomen or stomach bloody or cloudy urine bloody, black, or tarry stools blurred vision chills constipation continuing ringing or buzzing or other unexplained noise in the ears cough dark-colored urine decreased vision diarrhea difficulty with speaking difficulty with swallowing dizziness or lightheadedness fast heartbeat feeling of constant movement of self or surroundings greatly decreased frequency of urination or amount of urine hearing loss hives increased watering of the mouth indigestion itching joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools loss of appetite mood or mental changes muscle cramps or spasms muscle pain or stiffness nausea or vomiting pains in the stomach, side, or abdomen, possibly radiating to the back pale skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue red skin lesions, often with a purple center red, irritated eyes sensation of spinning shortness of breath skin rash sore throat sores, ulcers, or white spots on the lips or in the mouth swelling of the feet or lower legs swollen glands tightness in the chest unexplained bleeding or bruising unusual tiredness or weakness vomiting wheezing yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common Acid or sour stomach belching dizziness headache heartburn indigestion runny nose sleeplessness sneezing stomach discomfort, upset, or pain stuffy nose trouble sleeping unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Protonix Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Protonix Intravenous resources Protonix Intravenous Side Effects (in more detail) Protonix Intravenous Use in Pregnancy & Breastfeeding Drug Images Protonix Intravenous Drug Interactions Protonix Intravenous Support Group 27 Reviews for Protonix Intravenous - Add your own review/rating Compare Protonix Intravenous with other medications Barrett's Esophagus Duodenal Ulcer Erosive Esophagitis GERD Helicobacter Pylori Infection Peptic Ulcer Stomach Ulcer Stress Ulcer Prophylaxis Zollinger-Ellison Syndrome



peg-AP-ta-nib

Commonly used brand name(s)

In the U.S.

Macugen

Available Dosage Forms:

Solution

Therapeutic Class: Ophthalmologic Agent

Uses For pegaptanib

Pegaptanib is used to treat neovascular (wet) age-related macular degeneration (AMD). AMD is a disorder of the retina of the eye that causes blurring of vision or blindness .

pegaptanib is available only with your doctor's prescription .

Before Using pegaptanib

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pegaptanib, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pegaptanib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pegaptanib in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of pegaptanib in the elderly .

Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of pegaptanib. Make sure you tell your doctor if you have any other medical problems, especially:

Eye infection—Pegaptanib should NOT be used in patients with an infection in or around the eye . Glaucoma—pegaptanib may increase eye pressure after injection. Your doctor will monitor your eye pressure during the week after every injection . Proper Use of pegaptanib

A doctor will give you pegaptanib. Pegaptanib is given through a shot into your eye. .

Precautions While Using pegaptanib

Your doctor will want to check your progress at regular visits, especially during the first few weeks that you receive pegaptanib .

Serious eye problems may occur after treatment with pegaptanib. Check with your doctor immediately if your eye becomes red, sensitive to light, painful or develops a change in vision several days after your treatment.

pegaptanib Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common Bladder pain blindness bloody eye bloody or cloudy urine blurred vision burning, dry, or itching eyes cough producing mucus decreased vision or other changes in vision difficult, burning, or painful urination difficulty breathing discharge, excessive tearing disturbed color perception double vision drainage from eyes eye pain frequent urge to urinate gradual loss of vision halos around lights itching of eyelid looking through water lower back or side pain nausea night blindness overbright appearance of lights painful irritation of the clear front part of the eye redness, pain, swelling of eye, eyelid, or inner lining of eyelid seeing flashes or sparks of light seeing floating spots before the eyes shortness of breath sore eyes swelling of the eye tightness in chest tunnel vision vomiting wheezing Less Common Bigger, dilated, or enlarged pupils (black part of the eye) change in vision not present before treatment chest pain confusion decrease in frequency of urination decrease in urine volume difficulty in passing urine (dribbling) dizziness or lightheadedness dry mouth eye irritation fatigue feeling of constant movement of self or surroundings flushed, dry skin fruit-like breath odor headache hearing loss inability to speak increased hunger increased sensitivity of eyes to light increased thirst increased urination loss of consciousness numbness or tingling in face, arms, or legs seeing floaters, veil or curtain appearing across part of vision seizures sensation of spinning severe or sudden headache slurred speech stomachache sweating temporary blindness trouble speaking, thinking, or walking troubled breathing unexplained weight loss weakness in arm and/or leg on one side of the body, sudden and severe Incidence not determined Difficulty swallowing fast heartbeat hives itching puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue skin rash unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Diarrhea Less common Acid or sour stomach belching blistering, burning, crusting, dryness, or flaking of skin bruise difficulty in moving heartburn indigestion itching, scaling, severe redness, soreness, swelling of skin muscle pain or stiffness pain, swelling, or redness in joints stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: pegaptanib Intraocular side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More pegaptanib Intraocular resources Pegaptanib Intraocular Side Effects (in more detail) Pegaptanib Intraocular Use in Pregnancy & Breastfeeding Pegaptanib Intraocular Drug Interactions Pegaptanib Intraocular Support Group 0 Reviews for Pegaptanib Intraocular - Add your own review/rating Compare pegaptanib Intraocular with other medications Macular Degeneration



peg-fil-GRA-stim

Commonly used brand name(s)

In the U.S.

Neulasta

Available Dosage Forms:

Solution

Therapeutic Class: Hematopoietic

Pharmacologic Class: Colony Stimulating Factor

Uses For pegfilgrastim

Pegfilgrastim is a synthetic (man-made) version of a substance that is naturally produced in your body called a colony stimulating factor. It helps the bone marrow to make new white blood cells.

When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Pegfilgrastim is used to reduce the risk of infection while you are being treated with cancer medicines.

pegfilgrastim is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, pegfilgrastim is used in certain patients with the following medical conditions:

Harvesting of peripheral blood stem cells, prior to autologous stem-cell transplantation. Before Using pegfilgrastim

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pegfilgrastim, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pegfilgrastim or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pegfilgrastim in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pegfilgrastim in the elderly.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of pegfilgrastim. Make sure you tell your doctor if you have any other medical problems, especially:

Bone marrow cancer or other bone marrow problems—Pegfilgrastim may make cancer or other problems worse. Liver problems—Safety of pegfilgrastim in patients with liver problems has not been studied. Lung disease or breathing problems—Use with caution. May make these conditions worse. Peripheral blood progenitor cell (PBPC) mobilization—Use of pegfilgrastim is not recommended for PBPC mobilization. Sepsis (serious infection)—There have been reports of acute respiratory distress syndrome (ARDS) in patients who had a serious infection and were receiving a similar medicine called filgrastim. Sickle cell disease—Pegfilgrastim may increase the risk of unwanted effects. Proper Use of pegfilgrastim

pegfilgrastim is given as a shot under your skin. You may be taught how to give pegfilgrastim at home. Make sure you understand all of the instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

pegfilgrastim comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions about:

How to prepare the injection. The proper use of disposable syringes. How to give the injection. How long the injection can be stored at home.

If you have any questions about any of this, check with your doctor.

Dosing

The dose of pegfilgrastim will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of pegfilgrastim. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injectable dosage form: To increase white blood cell count: Adults—6 milligrams (mg) as a single injection one time every chemotherapy cycle. Children—Use and dose must be determined by your doctor. Missed Dose

pegfilgrastim needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Precautions While Using pegfilgrastim

It is very important that your doctor check your progress at regular visits to make sure that pegfilgrastim is working properly. Blood tests may be needed to check for unwanted effects.

The needle cover of the prefilled syringe contains dry natural rubber (a derivative of latex), which may cause an allergic reaction in people who are sensitive to latex. Tell your doctor if you have a latex allergy before you start using pegfilgrastim.

If you have left upper stomach pain or shoulder tip pain, contact your doctor right away. This could be a symptom of a serious side effect with the spleen.

Check with your doctor right away at the first sign of any infection such as fever; chills; cough; diarrhea; sore throat; or redness, swelling, or pain around a cut or sore.

Stop using pegfilgrastim and check with your doctor right away if you develop fever, shortness of breath, chest pain or tightness, fast breathing, or wheezing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS).

pegfilgrastim may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; swelling of the face, tongue, or throat; trouble with breathing; or chest pain after you receive the medicine.

You should not use pegfilgrastim for 14 days before and up to 24 hours after you receive cancer medicines.

pegfilgrastim Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Chills cough fever sore throat ulcers; sores, or white spots in the mouth Rare Bluish lips or skin pain, left upper abdomen or shoulder shortness of breath tightness in the chest troubled breathing wheezing Incidence not known Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site difficulty with swallowing dizziness fast heartbeat flushing or redness of the skin hives or welts itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs skin rash sores on the skin unusual tiredness or weakness unusually warm skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Abdominal or stomach pain acid or sour stomach belching bone pain change in sense of taste constipation cracked lips diarrhea hair loss or thinning of hair headache heartburn indigestion joint pain lack or loss of strength loss of appetite muscle soreness nausea stomach discomfort, upset, or pain swelling of the hands, ankles, feet, or lower legs swelling or inflammation of the mouth trouble sleeping vomiting weakness, generalized weight loss Incidence not known Body produces substance that can bind to drug making it less effective or cause side effects

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: pegfilgrastim Subcutaneous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More pegfilgrastim Subcutaneous resources Pegfilgrastim Subcutaneous Side Effects (in more detail) Pegfilgrastim Subcutaneous Use in Pregnancy & Breastfeeding Pegfilgrastim Subcutaneous Drug Interactions Pegfilgrastim Subcutaneous Support Group 7 Reviews for Pegfilgrastim Subcutaneous - Add your own review/rating Compare pegfilgrastim Subcutaneous with other medications Neutropenia Associated with Chemotherapy



Generic Name: tolnaftate (Topical route)

tol-NAF-tate

Commonly used brand name(s)

In the U.S.

Absorbine Jr. Antifungal Aftate Blis-To-Sol Dermasept Antifungal Fungi-Guard Podactin Q-Naftate Tinactin Tinaderm Ting

In Canada

Athlete's Foot Gel Dr. Scholl's Athlete's Foot Pitrex Scholl's Athlete's Foot Spray Scholl Tritin Antifungal Powder Scholl Tritin Antifungal Spray Powder Tinactin Aerosol Liquid Tinactin Aerosol Powder Tinactin Jock Itch Tinactin Plus Tinactin Plus Aerosol Powder

Available Dosage Forms:

Ointment Spray Cream Lotion Gel/Jelly Powder Solution

Therapeutic Class: Antifungal

Uses For Podactin

Tolnaftate belongs to the group of medicines called antifungals. It is used to treat some types of fungus infections. It may also be used together with medicines taken by mouth for fungus infections.

Tolnaftate is available without a prescription.

Before Using Podactin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Tolnaftate should not be used on children up to 2 years of age, unless otherwise directed by your doctor. Although there is no specific information comparing use of tolnaftate in children 2 years of age and older with use in other age groups, this medicine is not expected to cause different side effects or problems in children 2 years of age and older than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tolnaftate in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of tolnaftate

This section provides information on the proper use of a number of products that contain tolnaftate. It may not be specific to Podactin. Please read with care.

Before applying tolnaftate, wash the affected area and dry thoroughly. Then apply enough medicine to cover the affected area.

Keep this medicine away from the eyes.

For patients using the powder form of this medicine:

If the powder is used on the feet, sprinkle it between toes, on feet, and in socks and shoes.

For patients using the aerosol powder form of this medicine:

Shake well before using. From a distance of 6 to 10 inches, spray the powder on the affected areas. If it is used on the feet, spray it between toes, on feet, and in socks and shoes. Do not inhale the powder. Do not use near heat, near open flame, or while smoking.

For patients using the solution form of this medicine:

If tolnaftate solution becomes a solid, it may be dissolved by warming the closed container of medicine in warm water.

For patients using the aerosol solution form of this medicine:

Shake well before using. From a distance of 6 inches, spray the solution on the affected areas. If it is used on the feet, spray between toes and on feet. Do not inhale the vapors from the spray. Do not use near heat, near open flame, or while smoking.

To help clear up your infection completely, keep using this medicine for 2 weeks after burning, itching, or other symptoms have disappeared , unless otherwise directed by your doctor. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage forms (aerosol powder, aerosol solution, cream, gel, powder, or topical solution): For fungus infections: Adults and children 2 years of age and over—Apply to the affected area(s) of the skin two times a day. Children up to 2 years of age—Use is not recommended except under the advice and supervision of your doctor. Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Podactin

If your skin problem does not improve within 4 weeks, or if it becomes worse, check with your health care professional.

To help prevent reinfection after the period of treatment with this medicine, the powder or spray powder form of this medicine may be used each day after bathing and carefully drying the affected area.

Podactin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Skin irritation not present before use of this medicine

When you apply the aerosol solution form of this medicine, a mild temporary stinging may be expected.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Podactin Topical side effects (in more detail)

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More Podactin Topical resources Podactin Topical Side Effects (in more detail) Podactin Topical Use in Pregnancy & Breastfeeding Podactin Topical Support Group 0 Reviews for Podactin Topical - Add your own review/rating Compare Podactin Topical with other medications Tinea Corporis Tinea Cruris Tinea Pedis Tinea Versicolor



Class: Proton-pump Inhibitors



Class: Anticholinergic Agents



Pronunciation: pree-NATE-al muhl-tee-VYE-ta-mins/MIN-er-als/EYE-urn/FOE-lik AS-id



Pronunciation: PAN-kree-a-tin



Pronunciation: HYE-droe-KOR-ti-sone/pram-OX-een



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